AXL‐Mediated Drug Resistance in ALK‐Rearranged NSCLC Enhanced by GAS6 From Macrophages and MMP11 Positive Fibroblasts

Anaplastic lymphoma kinase (ALK) rearranged non‐small cell lung cancer (NSCLC) shows marked tumor shrinkage by ALK‐tyrosine kinase inhibitors (TKIs). However, tumors almost inevitably relapse owing to the development of acquired resistance. Resistance mechanisms include secondary ALK mutations and t...

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Veröffentlicht in:	Cancer science 2025-02
Hauptverfasser:	Utsumi, Takahiro, Mizuta, Hayato, Seto, Yosuke, Uchibori, Ken, Nishio, Makoto, Okamoto, Isamu, Katayama, Ryohei
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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