The pathogenic role of the BRCA2 c. 7847C >T (p.Ser2616Phe) variant in breast and ovarian cancer predisposition

Substantial numbers of variants of unknown significance (VUSs) have been identified in BRCA1 / 2 through genetic testing, which poses a significant clinical challenge because the contribution of these VUSs to cancer predisposition has not yet been determined. Here, we report 10 Japanese patients fro...

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Veröffentlicht in:	Cancer science 2023-07, Vol.114 (7), p.2993-3002
Hauptverfasser:	Yamazawa, Kazuki, Sugano, Kokichi, Tanakaya, Kohji, Inoue, Satomi, Murakami, Haruka, Nakashima, Moeko, Adachi, Masataka, Oki, Shinya, Makabe, Takeshi, Yamashita, Hiroshi, Ueki, Arisa, Sasaoka, Ayako, Nakashoji, Ayako, Kinoshita, Takayuki, Matsunaga, Tatsuo, Arai, Masami, Nakamura, Seigo, Miyata, Hiroaki, Ikegami, Masachika, Mano, Hiroyuki, Kohsaka, Shinji, Matsui, Akira
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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