Identification and characterisation of functional K ir 6.1-containing ATP-sensitive potassium channels in the cardiac ventricular sarcolemmal membrane

The canonical K 6.2/SUR2A ventricular K channel is highly ATP-sensitive and remains closed under normal physiological conditions. These channels activate only when prolonged metabolic compromise causes significant ATP depletion and then shortens the action potential to reduce contractile activity. P...

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Veröffentlicht in:	British journal of pharmacology 2024-09, Vol.181 (18), p.3380-3400
Hauptverfasser:	Brennan, Sean, Chen, Shen, Makwana, Samir, Esposito, Simona, McGuinness, Lauren R, Alnaimi, Abrar I M, Sims, Mark W, Patel, Manish, Aziz, Qadeer, Ojake, Leona, Roberts, James A, Sharma, Parveen, Lodwick, David, Tinker, Andrew, Barrett-Jolley, Richard, Dart, Caroline, Rainbow, Richard D
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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