BQ788 reveals glial ET B receptor modulation of neuronal cholinergic and nitrergic pathways to inhibit intestinal motility: Linked to postoperative ileus

ET-1 signalling modulates intestinal motility and inflammation, but the role of ET-1/ET receptor signalling is poorly understood. Enteric glia modulate normal motility and inflammation. We investigated whether glial ET signalling regulates neural-motor pathways of intestinal motility and inflammatio...

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Veröffentlicht in:	British journal of pharmacology 2023-10, Vol.180 (19), p.2550-2576
Hauptverfasser:	Mazzotta, Elvio, Grants, Iveta, Villalobos-Hernandez, Egina, Chaudhuri, Samhita, McClain, Jonathon L, Seguella, Luisa, Kendig, Derek M, Blakeney, Bryan A, Murthy, Srinivasa K, Schneider, Reiner, Leven, Patrick, Wehner, Sven, Harzman, Alan, Grider, John R, Gulbransen, Brian D, Christofi, Fedias L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cholinergic Agents - metabolism Gastrointestinal Motility Gliotoxin - metabolism Ileus - drug therapy Ileus - etiology Ileus - metabolism Inflammation - metabolism Mice Neuroglia Neurons - metabolism
Online-Zugang:	Volltext
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