Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA A receptor: In vitro and in vivo studies

In addition to binding to the classical high-affinity extracellular benzodiazepine binding site of the GABA receptor, some benzodiazepines occupy transmembrane inter-subunit anaesthetic sites that bind etomidate (β /α sites) or the barbiturate derivative R-mTFD-MPAB (α /β and γ /β sites). We aimed t...

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Veröffentlicht in:	British journal of pharmacology 2021-12, Vol.178 (24), p.4842-4858
Hauptverfasser:	McGrath, Megan, Hoyt, Helen, Pence, Andrea, Forman, Stuart A, Raines, Douglas E
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics - pharmacology Animals Benzodiazepines - metabolism Benzodiazepines - pharmacology Binding Sites Flumazenil - chemistry Flumazenil - pharmacology Receptors, GABA-A - metabolism Zebrafish - metabolism
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