A bivalent antihypertensive vaccine targeting L-type calcium channels and angiotensin AT 1 receptors

Hypertension has been the leading preventable cause of premature death worldwide. The aim of this study was to design a more efficient vaccine against novel targets for the treatment of hypertension. The epitope CE12, derived from the human L-type calcium channel (Ca 1.2), was designed and conjugate...

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Veröffentlicht in:	British journal of pharmacology 2020-01, Vol.177 (2), p.402-419
Hauptverfasser:	Wu, Hailang, Wang, Yiyi, Wang, Gongxin, Qiu, Zhihua, Hu, Xiajun, Zhang, Hongrong, Yan, Xiaole, Ke, Fan, Zou, Anruo, Wang, Min, Liao, Yuhua, Chen, Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Animals Blood Pressure - drug effects Calcium Channels, L-Type - immunology Calcium Channels, L-Type - metabolism Disease Models, Animal Epitopes Hypertension - immunology Hypertension - metabolism Hypertension - physiopathology Hypertension - prevention & control Male Mice, Inbred BALB C Rats, Inbred SHR Receptor, Angiotensin, Type 1 - immunology Receptor, Angiotensin, Type 1 - metabolism Vaccination Vaccines, Combined - pharmacology Vaccines, Virus-Like Particle - pharmacology
Online-Zugang:	Volltext
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