Towards functional selectivity for α6β3γ2 GABA A receptors: a series of novel pyrazoloquinolinones

The GABA receptors are ligand-gated ion channels, which play an important role in neurotransmission. Their variety of binding sites serves as an appealing target for many clinically relevant drugs. Here, we explored the functional selectivity of modulatory effects at specific extracellular α+/β- int...

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Veröffentlicht in:	British journal of pharmacology 2018-02, Vol.175 (3), p.419-428
Hauptverfasser:	Treven, Marco, Siebert, David C B, Holzinger, Raphael, Bampali, Konstantina, Fabjan, Jure, Varagic, Zdravko, Wimmer, Laurin, Steudle, Friederike, Scholze, Petra, Schnürch, Michael, Mihovilovic, Marko D, Ernst, Margot
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dose-Response Relationship, Drug Female GABA Modulators - chemistry GABA Modulators - pharmacology Pyrazoles - chemistry Pyrazoles - pharmacology Quinolones - chemistry Quinolones - pharmacology Rats Rats, Sprague-Dawley Receptors, GABA-A - physiology Xenopus laevis
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