Rubiarbonone C inhibits platelet-derived growth factor-induced proliferation and migration of vascular smooth muscle cells through the focal adhesion kinase, MAPK and STAT3 Tyr 705 signalling pathways

The proliferation and migration of vascular smooth muscle cells (VSMCs) induced by platelet-derived growth factor (PDGF) are important steps in cardiovascular diseases, including neointimal lesion formation, myocardial infarction and atherosclerosis. Here, we evaluated the rubiarbonone C-mediated si...

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Veröffentlicht in:	British journal of pharmacology 2017-11, Vol.174 (22), p.4140-4154
Hauptverfasser:	Park, Hyun-Soo, Quan, Khong Trong, Han, Joo-Hui, Jung, Sang-Hyuk, Lee, Do-Hyung, Jo, Eunji, Lim, Tae-Wan, Heo, Kyung-Sun, Na, MinKyun, Myung, Chang-Seon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Becaplermin Carotid Arteries - drug effects Carotid Arteries - pathology Carotid Arteries - surgery Cell Movement - drug effects Cell Proliferation - drug effects Focal Adhesion Protein-Tyrosine Kinases - metabolism Male Mice, Inbred C57BL Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Muscle, Smooth, Vascular - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Proto-Oncogene Proteins c-sis - pharmacology Rats, Sprague-Dawley Signal Transduction - drug effects STAT3 Transcription Factor - metabolism Triterpenes - pharmacology
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