Comparative analysis of IL 6 and IL 6 receptor gene polymorphisms in mastocytosis
Mastocytosis is a rare disease with reported high interleukin‐6 ( IL 6) levels influencing disease severity. The present study investigated polymorphisms within the genes that encode IL 6 and its receptor ( IL 6 R ) in relation to mastocytosis development in a case‐control design. Analysis of the IL...
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| Veröffentlicht in: | British journal of haematology 2013-01, Vol.160 (2), p.216-219 |
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| creator | Rausz, Eszter Szilágyi, Agnes Nedoszytko, Boguslaw Lange, Magdalena Niedoszytko, Marek Lautner‐Csorba, Orsolya Falus, András Aladzsity, István Kokai, Márta Valent, Peter Marschalko, Márta Hidvégi, Bernadett Szakonyi, József Csomor, Judit Várkonyi, Judit |
| description | Mastocytosis is a rare disease with reported high interleukin‐6 (
IL
6) levels influencing disease severity. The present study investigated polymorphisms within the genes that encode
IL
6 and its receptor (
IL
6
R
) in relation to mastocytosis development in a case‐control design. Analysis of the
IL
6
R
Asp358Ala polymorphism showed that carriers of the
AA
genotype had a 2·5‐fold lower risk for mastocytosis than those with the
AC
or
CC
genotypes. No association with mastocytosis was found for the
IL
6
−174
G
/
C
polymorphism, however, it may influence the effect of
IL
6
R
polymorphism. To the best of our knowledge this is the first study analysing
IL
6/
IL
6
R
polymorphisms in mastocytosis. |
| doi_str_mv | 10.1111/bjh.12086 |
| format | Article |
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IL
6) levels influencing disease severity. The present study investigated polymorphisms within the genes that encode
IL
6 and its receptor (
IL
6
R
) in relation to mastocytosis development in a case‐control design. Analysis of the
IL
6
R
Asp358Ala polymorphism showed that carriers of the
AA
genotype had a 2·5‐fold lower risk for mastocytosis than those with the
AC
or
CC
genotypes. No association with mastocytosis was found for the
IL
6
−174
G
/
C
polymorphism, however, it may influence the effect of
IL
6
R
polymorphism. To the best of our knowledge this is the first study analysing
IL
6/
IL
6
R
polymorphisms in mastocytosis.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/bjh.12086</identifier><language>eng</language><ispartof>British journal of haematology, 2013-01, Vol.160 (2), p.216-219</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c746-a7a6963c8107cec0b6c620e5af57d45c6661781c32d96aee42c5708dcb9c51ee3</citedby><cites>FETCH-LOGICAL-c746-a7a6963c8107cec0b6c620e5af57d45c6661781c32d96aee42c5708dcb9c51ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Rausz, Eszter</creatorcontrib><creatorcontrib>Szilágyi, Agnes</creatorcontrib><creatorcontrib>Nedoszytko, Boguslaw</creatorcontrib><creatorcontrib>Lange, Magdalena</creatorcontrib><creatorcontrib>Niedoszytko, Marek</creatorcontrib><creatorcontrib>Lautner‐Csorba, Orsolya</creatorcontrib><creatorcontrib>Falus, András</creatorcontrib><creatorcontrib>Aladzsity, István</creatorcontrib><creatorcontrib>Kokai, Márta</creatorcontrib><creatorcontrib>Valent, Peter</creatorcontrib><creatorcontrib>Marschalko, Márta</creatorcontrib><creatorcontrib>Hidvégi, Bernadett</creatorcontrib><creatorcontrib>Szakonyi, József</creatorcontrib><creatorcontrib>Csomor, Judit</creatorcontrib><creatorcontrib>Várkonyi, Judit</creatorcontrib><title>Comparative analysis of IL 6 and IL 6 receptor gene polymorphisms in mastocytosis</title><title>British journal of haematology</title><description>Mastocytosis is a rare disease with reported high interleukin‐6 (
IL
6) levels influencing disease severity. The present study investigated polymorphisms within the genes that encode
IL
6 and its receptor (
IL
6
R
) in relation to mastocytosis development in a case‐control design. Analysis of the
IL
6
R
Asp358Ala polymorphism showed that carriers of the
AA
genotype had a 2·5‐fold lower risk for mastocytosis than those with the
AC
or
CC
genotypes. No association with mastocytosis was found for the
IL
6
−174
G
/
C
polymorphism, however, it may influence the effect of
IL
6
R
polymorphism. To the best of our knowledge this is the first study analysing
IL
6/
IL
6
R
polymorphisms in mastocytosis.</description><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNotkEFLxDAUhIMouK4e_Ae5euj6Xtsk7VGKugsFEfZe0tdXt0vblKQI_fdW17nMMDBz-IR4RNjhquf6fNphDJm-EhtMtIpiTPFabADARAhpdivuQjgDYAIKN-KzcMNkvZ27b5Z2tP0SuiBdKw-l1GvRXIJn4ml2Xn7xyHJy_TI4P526MATZjXKwYXa0zG4d34ub1vaBH_59K45vr8diH5Uf74fipYzIpDqyxupcJ5QhGGKCWpOOgZVtlWlSRVprNBlSEje5tsxpTMpA1lCdk0LmZCueLrfkXQie22ry3WD9UiFUvyiqFUX1hyL5AcCdUWw</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Rausz, Eszter</creator><creator>Szilágyi, Agnes</creator><creator>Nedoszytko, Boguslaw</creator><creator>Lange, Magdalena</creator><creator>Niedoszytko, Marek</creator><creator>Lautner‐Csorba, Orsolya</creator><creator>Falus, András</creator><creator>Aladzsity, István</creator><creator>Kokai, Márta</creator><creator>Valent, Peter</creator><creator>Marschalko, Márta</creator><creator>Hidvégi, Bernadett</creator><creator>Szakonyi, József</creator><creator>Csomor, Judit</creator><creator>Várkonyi, Judit</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201301</creationdate><title>Comparative analysis of IL 6 and IL 6 receptor gene polymorphisms in mastocytosis</title><author>Rausz, Eszter ; Szilágyi, Agnes ; Nedoszytko, Boguslaw ; Lange, Magdalena ; Niedoszytko, Marek ; Lautner‐Csorba, Orsolya ; Falus, András ; Aladzsity, István ; Kokai, Márta ; Valent, Peter ; Marschalko, Márta ; Hidvégi, Bernadett ; Szakonyi, József ; Csomor, Judit ; Várkonyi, Judit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c746-a7a6963c8107cec0b6c620e5af57d45c6661781c32d96aee42c5708dcb9c51ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rausz, Eszter</creatorcontrib><creatorcontrib>Szilágyi, Agnes</creatorcontrib><creatorcontrib>Nedoszytko, Boguslaw</creatorcontrib><creatorcontrib>Lange, Magdalena</creatorcontrib><creatorcontrib>Niedoszytko, Marek</creatorcontrib><creatorcontrib>Lautner‐Csorba, Orsolya</creatorcontrib><creatorcontrib>Falus, András</creatorcontrib><creatorcontrib>Aladzsity, István</creatorcontrib><creatorcontrib>Kokai, Márta</creatorcontrib><creatorcontrib>Valent, Peter</creatorcontrib><creatorcontrib>Marschalko, Márta</creatorcontrib><creatorcontrib>Hidvégi, Bernadett</creatorcontrib><creatorcontrib>Szakonyi, József</creatorcontrib><creatorcontrib>Csomor, Judit</creatorcontrib><creatorcontrib>Várkonyi, Judit</creatorcontrib><collection>CrossRef</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rausz, Eszter</au><au>Szilágyi, Agnes</au><au>Nedoszytko, Boguslaw</au><au>Lange, Magdalena</au><au>Niedoszytko, Marek</au><au>Lautner‐Csorba, Orsolya</au><au>Falus, András</au><au>Aladzsity, István</au><au>Kokai, Márta</au><au>Valent, Peter</au><au>Marschalko, Márta</au><au>Hidvégi, Bernadett</au><au>Szakonyi, József</au><au>Csomor, Judit</au><au>Várkonyi, Judit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative analysis of IL 6 and IL 6 receptor gene polymorphisms in mastocytosis</atitle><jtitle>British journal of haematology</jtitle><date>2013-01</date><risdate>2013</risdate><volume>160</volume><issue>2</issue><spage>216</spage><epage>219</epage><pages>216-219</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><abstract>Mastocytosis is a rare disease with reported high interleukin‐6 (
IL
6) levels influencing disease severity. The present study investigated polymorphisms within the genes that encode
IL
6 and its receptor (
IL
6
R
) in relation to mastocytosis development in a case‐control design. Analysis of the
IL
6
R
Asp358Ala polymorphism showed that carriers of the
AA
genotype had a 2·5‐fold lower risk for mastocytosis than those with the
AC
or
CC
genotypes. No association with mastocytosis was found for the
IL
6
−174
G
/
C
polymorphism, however, it may influence the effect of
IL
6
R
polymorphism. To the best of our knowledge this is the first study analysing
IL
6/
IL
6
R
polymorphisms in mastocytosis.</abstract><doi>10.1111/bjh.12086</doi><tpages>4</tpages></addata></record> |
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| title | Comparative analysis of IL 6 and IL 6 receptor gene polymorphisms in mastocytosis |
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