Angiotensin II Receptor Blockers Inhibit the Generation of Epoxyeicosatrienoic Acid from Arachidonic Acid in Recombinant CYP 2C9, CYP 2J2 and Human Liver Microsomes

Cytochrome P450 ( CYP ) 2C9, CYP 2C8 and CYP 2J2 enzymes, which metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids, have cardioprotective effects including anti‐inflammation and vasodilation. We have recently shown that some angiotensin II receptor blockers ( ARB s) may inhibit AA metabol...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2017-10, Vol.121 (4), p.239-245
Hauptverfasser:	Senda, Asuna, Mukai, Yuji, Hayakawa, Toru, Kato, Yuka, Eliasson, Erik, Rane, Anders, Toda, Takaki, Inotsume, Nobuo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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