Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α 4 β 1/3 δ GABA A Receptor Subtypes

δ-Containing GABA receptors are located extrasynaptically and mediate tonic inhibition. Their involvement in brain physiology positions them as interesting drug targets. There is thus a continued interest in establishing reliable recombinant expression systems for δ-containing GABA receptors. Inconv...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2017-08, Vol.121 (2), p.119-129
Hauptverfasser:	Falk-Petersen, Christina B, Søgaard, Rikke, Madsen, Kenneth L, Klein, Anders B, Frølund, Bente, Wellendorph, Petrine
Format:	Artikel
Sprache:	eng
Schlagworte:	Fluorescent Dyes - chemistry GABA Agonists - pharmacology gamma-Aminobutyric Acid - metabolism HEK293 Cells Humans Immunohistochemistry Kinetics Membrane Potentials - drug effects Microscopy, Confocal Mutation Nerve Tissue Proteins - agonists Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Patch-Clamp Techniques Receptors, GABA-A - chemistry Receptors, GABA-A - genetics Receptors, GABA-A - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism Reproducibility of Results Zinc - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!