Positive correlation between organic anion transporter 1B function indicated by plasma concentration of coproporphyrin‐I and blood concentration of cyclosporin A in real‐world patients

Aims Cyclosporin A (CyA) has potent inhibitory activity on organic anion transporting polypeptide 1B (OATP1B), causing drug–drug interactions with its substrate drugs. 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropionate (CMPF), a uraemic toxin, has also been suggested to inhibit OATP1B activity. Recent st...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	British journal of clinical pharmacology 2023-05, Vol.89 (5), p.1672-1681
Hauptverfasser:	Watanabe, Takuma, Tanaka, Ryota, Suzuki, Yosuke, Sato, Haruki, Negami, Jun, Yoshijima, Chisato, Oda, Ayako, Ono, Hiroyuki, Tatsuta, Ryosuke, Ohno, Keiko, Itoh, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid, coproporphyrin‐I, cyclosporin A, organic anion transporter 1B Biomarkers Coproporphyrins - metabolism Coproporphyrins - pharmacology Cyclosporine Humans Liver-Specific Organic Anion Transporter 1 Organic Anion Transporters - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!