Foetal and neonatal exposure prediction and dosing evaluation for ampicillin using a physiologically‐based pharmacokinetic modelling approach

Aims Ampicillin is frequently used in neonates for the treatment of sepsis and as an intrapartum prophylaxis option for Group B Streptococcus. Pharmacokinetic data to guide ampicillin dosing in neonates and during the intrapartum period are limited. The objective of this study was to build a physiol...

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Veröffentlicht in:	British journal of clinical pharmacology 2023-04, Vol.89 (4), p.1402-1412
Hauptverfasser:	Li, Sanwang, Xie, Feifan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Ampicillin Female Fetus foetuses Humans Infant, Newborn Models, Biological neonates PBPK Pregnancy
Online-Zugang:	Volltext
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