A first in man study to evaluate the safety, pharmacokinetics and pharmacodynamics of RP7214, a dihydroorotate dehydrogenase inhibitor in healthy subjects

Dihydroorotate dehydrogenase (DHODH) is a mitochondrial enzyme that is essential for pyrimidine de novo synthesis. Rapidly growing cancer cells and replicating viruses are dependent on host cell nucleotides, the precursors of which are provided by DHODH. Hence, DHODH becomes an ideal target for phar...

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Veröffentlicht in:	British journal of clinical pharmacology 2023-03, Vol.89 (3), p.1127-1138
Hauptverfasser:	Nair, Ajit, Barde, Prajak J., Routhu, Kasi V., Viswanadha, Srikant, Veeraraghavan, Sridhar, Pak, Samuel, Peterson, Jeffrey A., Vakkalanka, Swaroop
Format:	Artikel
Sprache:	eng
Schlagworte:	COVID-19 Dihydroorotate Dehydrogenase Dose-Response Relationship, Drug Double-Blind Method Enzyme Inhibitors - adverse effects Healthy Volunteers Humans MAD RP7214 SAD SARS-CoV-2
Online-Zugang:	Volltext
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