Human pharmacokinetics of XBD173 and etifoxine distinguish their potential for pharmacodynamic effects mediated by translocator protein

XBD173 and etifoxine are translocator protein (TSPO) ligands that modulate inflammatory responses in preclinical models. Limited human pharmacokinetic data is available for either molecule, and the binding affinity of etifoxine for human TSPO is unknown. To allow for design of human challenge experi...

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Veröffentlicht in:	British journal of clinical pharmacology 2022-09, Vol.88 (9), p.4230-4236
Hauptverfasser:	Owen, David R., Phillips, Alexandra, O’Connor, Desmond, Grey, Gabrielle, Aimola, Lina, Nicholas, Richard, Matthews, Paul M.
Format:	Artikel
Sprache:	eng
Schlagworte:	anti‐inflammatory drugs brain, etifoxine Carrier Proteins - metabolism Humans Oxazines - pharmacokinetics Purines - pharmacology Receptors, GABA - metabolism translocator protein XBD173
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