Characterization of drug–drug interactions on the pharmacokinetic disposition of busulfan in paediatric patients during haematopoietic stem cell transplantation conditioning

Aim The study objective was to develop a population pharmacokinetic model for busulfan to comprehensively examine drug–drug interactions in paediatric patients undergoing haematopoietic stem cell transplantation. Currently, there is limited evidence to substantiate potential drug–drug interactions w...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	British journal of clinical pharmacology 2022-05, Vol.88 (5), p.2223-2235
Hauptverfasser:	Dunn, Allison, Moffett, Brady S., Ivaturi, Vijay, Gobburu, Jogarao V. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	busulfan Busulfan - pharmacokinetics Child Drug Interactions drug–drug interactions Glutathione Transferase - metabolism haematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation Humans paediatrics population pharmacokinetic modelling Retrospective Studies
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!