Human absorption, distribution, metabolism and excretion properties of drug molecules: a plethora of approaches

Human radiolabel studies are traditionally conducted to provide a definitive understanding of the human absorption, distribution, metabolism and excretion (ADME) properties of a drug. However, advances in technology over the past decade have allowed alternative methods to be employed to obtain both...

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Veröffentlicht in:	British journal of clinical pharmacology 2014-12, Vol.78 (6), p.1185-1200
Hauptverfasser:	Beaumont, Claire, Young, Graeme C., Cavalier, Tom, Young, Malcolm A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon Radioisotopes Chromatography, Liquid Humans investigational drugs Magnetic Resonance Spectroscopy metabolism Pharmacokinetics radioactive tracers Tandem Mass Spectrometry Tissue Distribution
Online-Zugang:	Volltext
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