Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics
Summary Background While carbon monoxide (CO) is a known toxin, it is now recognised that CO is also an important signalling molecule involved in physiology and pathophysiology. Aims To summarise our current understanding of the role of endogenous CO in the regulation of gastrointestinal physiology...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2013-10, Vol.38 (7), p.689-702 |
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| container_title | Alimentary pharmacology & therapeutics |
| container_volume | 38 |
| creator | Gibbons, S. J. Verhulst, P.‐J. Bharucha, A. Farrugia, G. |
| description | Summary
Background
While carbon monoxide (CO) is a known toxin, it is now recognised that CO is also an important signalling molecule involved in physiology and pathophysiology.
Aims
To summarise our current understanding of the role of endogenous CO in the regulation of gastrointestinal physiology and pathophysiology, and to potential therapeutic applications of modulating CO.
Methods
This review is based on a comprehensive search of the Ovid Medline comprehensive database and supplemented by our ongoing studies evaluating the role of CO in gastrointestinal physiology and pathophysiology.
Results
Carbon monoxide derived from haem oxygenase (HO)‐2 is predominantly involved in neuromodulation and in setting the smooth muscle membrane potential, while CO derived from HO‐1 has anti‐inflammatory and antioxidative properties, which protect gastrointestinal smooth muscle from damage caused by injury or inflammation. Exogenous CO is being explored as a therapeutic agent in a variety of gastrointestinal disorders, including diabetic gastroparesis, post‐operative ileus, organ transplantation, inflammatory bowel disease and sepsis. However, identifying the appropriate mechanism for safely delivering CO in humans is a major challenge.
Conclusions
Carbon monoxide is an important regulator of gastrointestinal function and protects the gastrointestinal tract against noxious injury. CO is a promising therapeutic target in conditions associated with gastrointestinal injury and inflammation. Elucidating the mechanisms by which CO works and developing safe CO delivery mechanisms are necessary to refine therapeutic strategies. |
| doi_str_mv | 10.1111/apt.12467 |
| format | Article |
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Background
While carbon monoxide (CO) is a known toxin, it is now recognised that CO is also an important signalling molecule involved in physiology and pathophysiology.
Aims
To summarise our current understanding of the role of endogenous CO in the regulation of gastrointestinal physiology and pathophysiology, and to potential therapeutic applications of modulating CO.
Methods
This review is based on a comprehensive search of the Ovid Medline comprehensive database and supplemented by our ongoing studies evaluating the role of CO in gastrointestinal physiology and pathophysiology.
Results
Carbon monoxide derived from haem oxygenase (HO)‐2 is predominantly involved in neuromodulation and in setting the smooth muscle membrane potential, while CO derived from HO‐1 has anti‐inflammatory and antioxidative properties, which protect gastrointestinal smooth muscle from damage caused by injury or inflammation. Exogenous CO is being explored as a therapeutic agent in a variety of gastrointestinal disorders, including diabetic gastroparesis, post‐operative ileus, organ transplantation, inflammatory bowel disease and sepsis. However, identifying the appropriate mechanism for safely delivering CO in humans is a major challenge.
Conclusions
Carbon monoxide is an important regulator of gastrointestinal function and protects the gastrointestinal tract against noxious injury. CO is a promising therapeutic target in conditions associated with gastrointestinal injury and inflammation. Elucidating the mechanisms by which CO works and developing safe CO delivery mechanisms are necessary to refine therapeutic strategies.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/apt.12467</identifier><identifier>PMID: 23992228</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Animals ; Anti-Inflammatory Agents - therapeutic use ; Biological and medical sciences ; Carbon Monoxide - administration & dosage ; Carbon Monoxide - metabolism ; Carbon Monoxide - therapeutic use ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal Diseases - drug therapy ; Gastrointestinal Diseases - physiopathology ; Gastrointestinal Tract - physiology ; Gastrointestinal Tract - physiopathology ; Heme Oxygenase (Decyclizing) - metabolism ; Heme Oxygenase-1 - metabolism ; Humans ; Inflammation - drug therapy ; Intestine. Mesentery ; Muscle, Smooth - metabolism ; Sepsis - drug therapy ; Vertebrates: digestive system</subject><ispartof>Alimentary pharmacology & therapeutics, 2013-10, Vol.38 (7), p.689-702</ispartof><rights>2013 John Wiley & Sons Ltd</rights><rights>2014 INIST-CNRS</rights><rights>2013 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4567-be9dea1c3418aa70841cde340efa3e8d2ee318eddf75a118740696f3c3039af03</citedby><cites>FETCH-LOGICAL-c4567-be9dea1c3418aa70841cde340efa3e8d2ee318eddf75a118740696f3c3039af03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapt.12467$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapt.12467$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27696495$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23992228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gibbons, S. J.</creatorcontrib><creatorcontrib>Verhulst, P.‐J.</creatorcontrib><creatorcontrib>Bharucha, A.</creatorcontrib><creatorcontrib>Farrugia, G.</creatorcontrib><title>Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
While carbon monoxide (CO) is a known toxin, it is now recognised that CO is also an important signalling molecule involved in physiology and pathophysiology.
Aims
To summarise our current understanding of the role of endogenous CO in the regulation of gastrointestinal physiology and pathophysiology, and to potential therapeutic applications of modulating CO.
Methods
This review is based on a comprehensive search of the Ovid Medline comprehensive database and supplemented by our ongoing studies evaluating the role of CO in gastrointestinal physiology and pathophysiology.
Results
Carbon monoxide derived from haem oxygenase (HO)‐2 is predominantly involved in neuromodulation and in setting the smooth muscle membrane potential, while CO derived from HO‐1 has anti‐inflammatory and antioxidative properties, which protect gastrointestinal smooth muscle from damage caused by injury or inflammation. Exogenous CO is being explored as a therapeutic agent in a variety of gastrointestinal disorders, including diabetic gastroparesis, post‐operative ileus, organ transplantation, inflammatory bowel disease and sepsis. However, identifying the appropriate mechanism for safely delivering CO in humans is a major challenge.
Conclusions
Carbon monoxide is an important regulator of gastrointestinal function and protects the gastrointestinal tract against noxious injury. CO is a promising therapeutic target in conditions associated with gastrointestinal injury and inflammation. Elucidating the mechanisms by which CO works and developing safe CO delivery mechanisms are necessary to refine therapeutic strategies.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Carbon Monoxide - administration & dosage</subject><subject>Carbon Monoxide - metabolism</subject><subject>Carbon Monoxide - therapeutic use</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal Diseases - drug therapy</subject><subject>Gastrointestinal Diseases - physiopathology</subject><subject>Gastrointestinal Tract - physiology</subject><subject>Gastrointestinal Tract - physiopathology</subject><subject>Heme Oxygenase (Decyclizing) - metabolism</subject><subject>Heme Oxygenase-1 - metabolism</subject><subject>Humans</subject><subject>Inflammation - drug therapy</subject><subject>Intestine. Mesentery</subject><subject>Muscle, Smooth - metabolism</subject><subject>Sepsis - drug therapy</subject><subject>Vertebrates: digestive system</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtOw0AQRVcIREKg4AfQNhQUTvbhJ10U8ZIigVCozWQ9ThY5trW7IfjvWXCAimmmmDP3SoeQc87G3M8EWjfmIoyTAzLkMo4CwWR8SIZMxFkgUi4H5MTaN8ZYnDBxTAZCZpkQIh2S12d817ijYJxWFV5TBWbZ1HTT1M2HLpDqmq7AOtPo2qF1uoaKtuvO6qZqVh2FuqDaWdo2Dmun_dE_uDUaaHHrI-0pOSqhsni23yPycnuzmN0H88e7h9l0HqgwipNgiVmBwJUMeQqQsDTkqkAZMixBYloIRMlTLIoyiYDzNAlZnMWlVJLJDEomR-Sqz1WmsdZgmbdGb8B0OWf5l6XcW8q_LXn2omfb7XKDxS_5o8UDl3sArIKqNFArbf-4xHeHWeS5Sc_tdIXd_4359GnRV38Cu5GAng</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Gibbons, S. J.</creator><creator>Verhulst, P.‐J.</creator><creator>Bharucha, A.</creator><creator>Farrugia, G.</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201310</creationdate><title>Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics</title><author>Gibbons, S. J. ; Verhulst, P.‐J. ; Bharucha, A. ; Farrugia, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4567-be9dea1c3418aa70841cde340efa3e8d2ee318eddf75a118740696f3c3039af03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Carbon Monoxide - administration & dosage</topic><topic>Carbon Monoxide - metabolism</topic><topic>Carbon Monoxide - therapeutic use</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal Diseases - drug therapy</topic><topic>Gastrointestinal Diseases - physiopathology</topic><topic>Gastrointestinal Tract - physiology</topic><topic>Gastrointestinal Tract - physiopathology</topic><topic>Heme Oxygenase (Decyclizing) - metabolism</topic><topic>Heme Oxygenase-1 - metabolism</topic><topic>Humans</topic><topic>Inflammation - drug therapy</topic><topic>Intestine. Mesentery</topic><topic>Muscle, Smooth - metabolism</topic><topic>Sepsis - drug therapy</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gibbons, S. J.</creatorcontrib><creatorcontrib>Verhulst, P.‐J.</creatorcontrib><creatorcontrib>Bharucha, A.</creatorcontrib><creatorcontrib>Farrugia, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gibbons, S. J.</au><au>Verhulst, P.‐J.</au><au>Bharucha, A.</au><au>Farrugia, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2013-10</date><risdate>2013</risdate><volume>38</volume><issue>7</issue><spage>689</spage><epage>702</epage><pages>689-702</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background
While carbon monoxide (CO) is a known toxin, it is now recognised that CO is also an important signalling molecule involved in physiology and pathophysiology.
Aims
To summarise our current understanding of the role of endogenous CO in the regulation of gastrointestinal physiology and pathophysiology, and to potential therapeutic applications of modulating CO.
Methods
This review is based on a comprehensive search of the Ovid Medline comprehensive database and supplemented by our ongoing studies evaluating the role of CO in gastrointestinal physiology and pathophysiology.
Results
Carbon monoxide derived from haem oxygenase (HO)‐2 is predominantly involved in neuromodulation and in setting the smooth muscle membrane potential, while CO derived from HO‐1 has anti‐inflammatory and antioxidative properties, which protect gastrointestinal smooth muscle from damage caused by injury or inflammation. Exogenous CO is being explored as a therapeutic agent in a variety of gastrointestinal disorders, including diabetic gastroparesis, post‐operative ileus, organ transplantation, inflammatory bowel disease and sepsis. However, identifying the appropriate mechanism for safely delivering CO in humans is a major challenge.
Conclusions
Carbon monoxide is an important regulator of gastrointestinal function and protects the gastrointestinal tract against noxious injury. CO is a promising therapeutic target in conditions associated with gastrointestinal injury and inflammation. Elucidating the mechanisms by which CO works and developing safe CO delivery mechanisms are necessary to refine therapeutic strategies.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>23992228</pmid><doi>10.1111/apt.12467</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Animals Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Carbon Monoxide - administration & dosage Carbon Monoxide - metabolism Carbon Monoxide - therapeutic use Fundamental and applied biological sciences. Psychology Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - physiopathology Gastrointestinal Tract - physiology Gastrointestinal Tract - physiopathology Heme Oxygenase (Decyclizing) - metabolism Heme Oxygenase-1 - metabolism Humans Inflammation - drug therapy Intestine. Mesentery Muscle, Smooth - metabolism Sepsis - drug therapy Vertebrates: digestive system |
| title | Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics |
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