Topiramate pharmacokinetics in neonates undergoing therapeutic hypothermia and proposal of an optimised dosing schedule

Aim The adequate dosing of topiramate in neonates undergoing therapeutic hypothermia has not been established. The aim of this study was to design a dosing schedule capable of providing topiramate serum concentrations within the accepted therapeutic range. Methods Neonates (n = 52) with hypoxic isch...

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Veröffentlicht in:	ACTA PAEDIATRICA 2020-02, Vol.109 (2), p.300-308
Hauptverfasser:	Marques, María Remedios, Garcia‐Robles, Ana, Usach, Iris, Vento, Maximo, Poveda, José Luis, Peris, José Esteban, Mangas‐Sanjuan, Victor
Format:	Artikel
Sprache:	eng
Schlagworte:	Dosage Encephalopathy Humans Hypothermia Hypothermia, Induced Hypoxia Hypoxia-Ischemia, Brain - therapy hypoxic ischaemic encephalopathy Infant, Newborn Life Sciences & Biomedicine Neonates Pediatrics Pharmacokinetics population pharmacokinetics Schedules Science & Technology Seizures therapeutic hypothermia Topiramate topiramate dosing
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