Annexin A1 restores Aβ 1-42 -induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway

The blood-brain barrier (BBB) is composed of brain capillary endothelial cells and has an important role in maintaining homeostasis of the brain separating the blood from the parenchyma of the central nervous system (CNS). It is widely known that disruption of the BBB occurs in various neurodegenera...

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Veröffentlicht in:	Aging cell 2017-02, Vol.16 (1), p.149-161
Hauptverfasser:	Park, Jong-Chan, Baik, Sung Hoon, Han, Sun-Ho, Cho, Hyun Jin, Choi, Hyunjung, Kim, Haeng Jun, Choi, Heesun, Lee, Wonik, Kim, Dong Kyu, Mook-Jung, Inhee
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - blood Alzheimer Disease - pathology Amyloid beta-Peptides - toxicity Animals Annexin A1 - blood Annexin A1 - metabolism Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Capillaries - drug effects Capillaries - metabolism Female Humans Male Mice, Transgenic Peptide Fragments - toxicity Pericytes - drug effects Pericytes - metabolism Receptors, Formyl Peptide - blood Receptors, Lipoxin - blood Recombinant Proteins - pharmacology rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism rhoA GTP-Binding Protein - metabolism Signal Transduction - drug effects Tight Junctions - drug effects Tight Junctions - metabolism
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