Modulation of Age-related Development of Contact Sensitivity in Mice by Adult Thymectomy
The effect of adult thymectomy on antibody production and on the development of contact sensitivity to picryl chloride in mice of different ages was studied. An age-dependent decline in the ability to develop contact sensitivity was found to be counteracted by thymectomy. In contrast, antibody produ...
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| Veröffentlicht in: | Journal of investigative dermatology 1978-11, Vol.71 (5), p.299-300 |
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| container_title | Journal of investigative dermatology |
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| creator | Roupe, Gösta |
| description | The effect of adult thymectomy on antibody production and on the development of contact sensitivity to picryl chloride in mice of different ages was studied. An age-dependent decline in the ability to develop contact sensitivity was found to be counteracted by thymectomy. In contrast, antibody production was regularly decreased by thymectomy in mice of all ages. A hypothesis is put forward in which the development of contact sensitivity may be regulated by long-lived thymus-dependent suppressor cells which do not affect antibody formation. |
| doi_str_mv | 10.1111/1523-1747.ep12529253 |
| format | Article |
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An age-dependent decline in the ability to develop contact sensitivity was found to be counteracted by thymectomy. In contrast, antibody production was regularly decreased by thymectomy in mice of all ages. 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An age-dependent decline in the ability to develop contact sensitivity was found to be counteracted by thymectomy. In contrast, antibody production was regularly decreased by thymectomy in mice of all ages. A hypothesis is put forward in which the development of contact sensitivity may be regulated by long-lived thymus-dependent suppressor cells which do not affect antibody formation.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Antibodies - analysis</subject><subject>Dermatitis, Contact - etiology</subject><subject>Dermatitis, Contact - immunology</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Picryl Chloride - adverse effects</subject><subject>T-Lymphocytes - immunology</subject><subject>Thymectomy</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtqwzAQRUXpK037B1noB5xKsmTFm0JIn5DQRVPITsjSqFWJLWOrAf99bVzSXWczzFzuZeYgNKNkTvu6pYKlCZVczqGmTLCcifQETY7rUzQhhLGEEba7RFdt-0UIzbhYXKDzlOQ8ZxO02wT7vdfRhwoHh5cfkDTQz2DxPRxgH-oSqjhIq1BFbSJ-g6r10R987LCv8MYbwEWHl31MxNvPrgQTQ9ldozOn9y3c_PYpen982K6ek_Xr08tquU4MJywmwjgHDDR3aWaBECmMloKTXBSp1YuFk7mQ1jqpqcuAaypJYYgAl2eWaWDpFPEx1zShbRtwqm58qZtOUaIGTGrgoQYe6g9Tb5uNtvq7KMEeTSOXXr4bZehPP3hoVGs8VAasb_r_lA3-__wfgxB4lw</recordid><startdate>197811</startdate><enddate>197811</enddate><creator>Roupe, Gösta</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197811</creationdate><title>Modulation of Age-related Development of Contact Sensitivity in Mice by Adult Thymectomy</title><author>Roupe, Gösta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-5cffe2ea4f36de0075ca754095b3da88f7957ddf7a1f6e4a170bc05ef96d2ae23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Antibodies - analysis</topic><topic>Dermatitis, Contact - etiology</topic><topic>Dermatitis, Contact - immunology</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Picryl Chloride - adverse effects</topic><topic>T-Lymphocytes - immunology</topic><topic>Thymectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roupe, Gösta</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roupe, Gösta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of Age-related Development of Contact Sensitivity in Mice by Adult Thymectomy</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>1978-11</date><risdate>1978</risdate><volume>71</volume><issue>5</issue><spage>299</spage><epage>300</epage><pages>299-300</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><abstract>The effect of adult thymectomy on antibody production and on the development of contact sensitivity to picryl chloride in mice of different ages was studied. 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| fulltext | fulltext |
| identifier | ISSN: 0022-202X |
| ispartof | Journal of investigative dermatology, 1978-11, Vol.71 (5), p.299-300 |
| issn | 0022-202X 1523-1747 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Age Factors Animals Antibodies - analysis Dermatitis, Contact - etiology Dermatitis, Contact - immunology Mice Mice, Inbred CBA Picryl Chloride - adverse effects T-Lymphocytes - immunology Thymectomy |
| title | Modulation of Age-related Development of Contact Sensitivity in Mice by Adult Thymectomy |
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