Prolonged Skin Photosensitization Induced by Methoxsalen and Subphototoxic UVA Irradiation

Topical 8-methoxypsoralen (8-MOP) was used to briefly provide free psoralen sufficient for marked cutaneous photosensitization, but only a small dose of UVA was delivered initially, in an effort to produce many monoadducts but few crosslinks. After ample time for clearance of the remaining free psor...

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Veröffentlicht in:	Journal of investigative dermatology 1984-03, Vol.82 (3), p.219-222
Hauptverfasser:	Gange, Richard W., Levins, Paul, Murray, John, Anderson, R. Rox, Parrish, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences DNA - radiation effects Drug toxicity and drugs side effects treatment Humans Medical sciences Mutation Pharmacology. Drug treatments Photochemotherapy Photosensitivity Disorders - chemically induced Photosensitivity Disorders - pathology PUVA Therapy - methods Skin - drug effects Time Factors Toxicity: skin, dermoskeleton
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