Optimal Design of Neuroprotective Focal Brain Cooling Device Using Surrogate Model Approach

Focal brain cooling (FBC) is a treatment for refractory epilepsy to suppress epileptic discharges from an epileptic focus. Our wearable FBC system under development consists of a recirculating coolant apparatus and a battery located extracorporeally, and a cooling device made of titanium with water...

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Veröffentlicht in:	IEEE transactions on medical robotics and bionics 2020-11, Vol.2 (4), p.681-691
Hauptverfasser:	Abe, Takuto, Fujiwara, Koichi, Inoue, Takao, Kubo, Takatomi, Yamakawa, Toshitaka, Nomura, Sadahiro, Suzuki, Michiyasu, Kano, Manabu
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Brain modeling Computer simulation Cooling Epilepsy Finite element analysis Finite element method Finite element simulation focal brain cooling Genetic algorithms Low pressure Miniaturization Multiple objective analysis non-dominated sorting genetic algorithm II Optimization Performance evaluation Pressure drop Pressure loss Sorting algorithms surrogate model
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