The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated B act complex

The precise function of the trimeric retention and splicing (RES) complex in pre-mRNA splicing remains unclear. Here we dissected the role of RES during the assembly and activation of yeast spliceosomes. The efficiency of pre-mRNA splicing was significantly lower in the absence of the RES protein Sn...

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Veröffentlicht in:	Genes & development 2017-12, Vol.31 (23-24), p.2416-2429
Hauptverfasser:	Bao, Penghui, Will, Cindy L, Urlaub, Henning, Boon, Kum-Loong, Lührmann, Reinhard
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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