Streptomyces: a natural source of anti-Candida agents: This article is part of the Candida collection
Introduction. There is an urgent need to source new compounds that can combat the current threat of serious infection caused by Candida spp. and contend with the problem of antimicrobial resistance. Gap. A synthesis of the evidence available from the current literature is needed to identify promisin...
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| Veröffentlicht in: | Journal of medical microbiology 2023-11, Vol.72 (11) |
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| container_title | Journal of medical microbiology |
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| creator | Martins, Nathália da Rosa Coelho Rodrigues da Silva, Aldo Ratcliffe, Norman Evangelho, Victor Gustavo Oliveira Castro, Helena Carla Quinn, Gerry A. |
| description | Introduction.
There is an urgent need to source new compounds that can combat the current threat of serious infection caused by
Candida
spp. and contend with the problem of antimicrobial resistance.
Gap.
A synthesis of the evidence available from the current literature is needed to identify promising antifungal chemotherapeutics.
Aim.
To highlight anti-
Candida
compounds derived from
Streptomyces
spp. (a well-known source of antimicrobial compounds) that could translate to potential candidates for future clinical practice.
Methodology.
A comprehensive review was conducted across three scientific literature databases spanning a 13-year period.
Results.
We identified 151 compounds with anti-
Candida
activity. Amongst these, 40 were reported with very strong inhibitory activity, having minimum inhibitory concentrations (MICs) against
Candida
spp. of |
| doi_str_mv | 10.1099/jmm.0.001777 |
| format | Article |
| fullrecord | <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_1099_jmm_0_001777</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1099_jmm_0_001777</sourcerecordid><originalsourceid>FETCH-crossref_primary_10_1099_jmm_0_0017773</originalsourceid><addsrcrecordid>eNqVzrsOgjAUgOHGaCJeNh-gD2DxlFuDq9G4696cQDEQ2pK2DLy9En0Bp3_5h4-QA4eYQ1meOq1jiAG4EGJBIp6JlOVFli1JBJAkLCl4viYb77v5SdMyIvkjODUEq6dK-TNFajCMDnvq7egqRW1D0YSWXdDUbY0UX8oEvyOrBnuv9r9uyfF2fV7urHLWe6caObhWo5skBznT5IcmQX5p6Z_7G1sjQGM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Streptomyces: a natural source of anti-Candida agents: This article is part of the Candida collection</title><source>Microbiology Society</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Martins, Nathália da Rosa Coelho ; Rodrigues da Silva, Aldo ; Ratcliffe, Norman ; Evangelho, Victor Gustavo Oliveira ; Castro, Helena Carla ; Quinn, Gerry A.</creator><creatorcontrib>Martins, Nathália da Rosa Coelho ; Rodrigues da Silva, Aldo ; Ratcliffe, Norman ; Evangelho, Victor Gustavo Oliveira ; Castro, Helena Carla ; Quinn, Gerry A.</creatorcontrib><description>Introduction.
There is an urgent need to source new compounds that can combat the current threat of serious infection caused by
Candida
spp. and contend with the problem of antimicrobial resistance.
Gap.
A synthesis of the evidence available from the current literature is needed to identify promising antifungal chemotherapeutics.
Aim.
To highlight anti-
Candida
compounds derived from
Streptomyces
spp. (a well-known source of antimicrobial compounds) that could translate to potential candidates for future clinical practice.
Methodology.
A comprehensive review was conducted across three scientific literature databases spanning a 13-year period.
Results.
We identified 151 compounds with anti-
Candida
activity. Amongst these, 40 were reported with very strong inhibitory activity, having minimum inhibitory concentrations (MICs) against
Candida
spp. of <3.5 µg ml
−1
, 66 compounds were considered strong inhibitors and 45 compounds exhibited moderate inhibitory potential. From an analysis of the MICs, we deduced that the actinomycin-like compounds RSP01 and RSP02 were probably the most promising anti-
Candida
compounds. Other antifungals of note included filipin-like compounds, which demonstrated superior inhibition to amphotericin B and activity against
Candida glabrata
and
Candida krusei
, and bafilomycin derivatives, which had substantial inhibition against
Candida parapsilosis
.
Conclusion.
It is essential to recognize the limitations inherent in the quest for new antifungals, which encompass toxicity,
in vivo
effectiveness and constraints associated with limited data access. However, further investigation through in-depth study and emerging technologies is of paramount importance, given that there are still many more compounds to discover. This review highlights the importance of antifungal compounds derived from
Streptomyces
, which demonstrate robust inhibition, and, in many cases, low toxicity, making them promising candidates for the development of novel antifungal agents.</description><identifier>ISSN: 0022-2615</identifier><identifier>EISSN: 1473-5644</identifier><identifier>DOI: 10.1099/jmm.0.001777</identifier><language>eng</language><ispartof>Journal of medical microbiology, 2023-11, Vol.72 (11)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-crossref_primary_10_1099_jmm_0_0017773</cites><orcidid>0000-0001-8538-0636 ; 0000-0003-0023-2621 ; 0000-0001-6999-5585 ; 0000-0002-4083-7855 ; 0000-0001-5283-1541 ; 0000-0002-0560-0115</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3733,27901,27902</link.rule.ids></links><search><creatorcontrib>Martins, Nathália da Rosa Coelho</creatorcontrib><creatorcontrib>Rodrigues da Silva, Aldo</creatorcontrib><creatorcontrib>Ratcliffe, Norman</creatorcontrib><creatorcontrib>Evangelho, Victor Gustavo Oliveira</creatorcontrib><creatorcontrib>Castro, Helena Carla</creatorcontrib><creatorcontrib>Quinn, Gerry A.</creatorcontrib><title>Streptomyces: a natural source of anti-Candida agents: This article is part of the Candida collection</title><title>Journal of medical microbiology</title><description>Introduction.
There is an urgent need to source new compounds that can combat the current threat of serious infection caused by
Candida
spp. and contend with the problem of antimicrobial resistance.
Gap.
A synthesis of the evidence available from the current literature is needed to identify promising antifungal chemotherapeutics.
Aim.
To highlight anti-
Candida
compounds derived from
Streptomyces
spp. (a well-known source of antimicrobial compounds) that could translate to potential candidates for future clinical practice.
Methodology.
A comprehensive review was conducted across three scientific literature databases spanning a 13-year period.
Results.
We identified 151 compounds with anti-
Candida
activity. Amongst these, 40 were reported with very strong inhibitory activity, having minimum inhibitory concentrations (MICs) against
Candida
spp. of <3.5 µg ml
−1
, 66 compounds were considered strong inhibitors and 45 compounds exhibited moderate inhibitory potential. From an analysis of the MICs, we deduced that the actinomycin-like compounds RSP01 and RSP02 were probably the most promising anti-
Candida
compounds. Other antifungals of note included filipin-like compounds, which demonstrated superior inhibition to amphotericin B and activity against
Candida glabrata
and
Candida krusei
, and bafilomycin derivatives, which had substantial inhibition against
Candida parapsilosis
.
Conclusion.
It is essential to recognize the limitations inherent in the quest for new antifungals, which encompass toxicity,
in vivo
effectiveness and constraints associated with limited data access. However, further investigation through in-depth study and emerging technologies is of paramount importance, given that there are still many more compounds to discover. This review highlights the importance of antifungal compounds derived from
Streptomyces
, which demonstrate robust inhibition, and, in many cases, low toxicity, making them promising candidates for the development of novel antifungal agents.</description><issn>0022-2615</issn><issn>1473-5644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqVzrsOgjAUgOHGaCJeNh-gD2DxlFuDq9G4696cQDEQ2pK2DLy9En0Bp3_5h4-QA4eYQ1meOq1jiAG4EGJBIp6JlOVFli1JBJAkLCl4viYb77v5SdMyIvkjODUEq6dK-TNFajCMDnvq7egqRW1D0YSWXdDUbY0UX8oEvyOrBnuv9r9uyfF2fV7urHLWe6caObhWo5skBznT5IcmQX5p6Z_7G1sjQGM</recordid><startdate>20231122</startdate><enddate>20231122</enddate><creator>Martins, Nathália da Rosa Coelho</creator><creator>Rodrigues da Silva, Aldo</creator><creator>Ratcliffe, Norman</creator><creator>Evangelho, Victor Gustavo Oliveira</creator><creator>Castro, Helena Carla</creator><creator>Quinn, Gerry A.</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-8538-0636</orcidid><orcidid>https://orcid.org/0000-0003-0023-2621</orcidid><orcidid>https://orcid.org/0000-0001-6999-5585</orcidid><orcidid>https://orcid.org/0000-0002-4083-7855</orcidid><orcidid>https://orcid.org/0000-0001-5283-1541</orcidid><orcidid>https://orcid.org/0000-0002-0560-0115</orcidid></search><sort><creationdate>20231122</creationdate><title>Streptomyces: a natural source of anti-Candida agents</title><author>Martins, Nathália da Rosa Coelho ; Rodrigues da Silva, Aldo ; Ratcliffe, Norman ; Evangelho, Victor Gustavo Oliveira ; Castro, Helena Carla ; Quinn, Gerry A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-crossref_primary_10_1099_jmm_0_0017773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martins, Nathália da Rosa Coelho</creatorcontrib><creatorcontrib>Rodrigues da Silva, Aldo</creatorcontrib><creatorcontrib>Ratcliffe, Norman</creatorcontrib><creatorcontrib>Evangelho, Victor Gustavo Oliveira</creatorcontrib><creatorcontrib>Castro, Helena Carla</creatorcontrib><creatorcontrib>Quinn, Gerry A.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martins, Nathália da Rosa Coelho</au><au>Rodrigues da Silva, Aldo</au><au>Ratcliffe, Norman</au><au>Evangelho, Victor Gustavo Oliveira</au><au>Castro, Helena Carla</au><au>Quinn, Gerry A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Streptomyces: a natural source of anti-Candida agents: This article is part of the Candida collection</atitle><jtitle>Journal of medical microbiology</jtitle><date>2023-11-22</date><risdate>2023</risdate><volume>72</volume><issue>11</issue><issn>0022-2615</issn><eissn>1473-5644</eissn><abstract>Introduction.
There is an urgent need to source new compounds that can combat the current threat of serious infection caused by
Candida
spp. and contend with the problem of antimicrobial resistance.
Gap.
A synthesis of the evidence available from the current literature is needed to identify promising antifungal chemotherapeutics.
Aim.
To highlight anti-
Candida
compounds derived from
Streptomyces
spp. (a well-known source of antimicrobial compounds) that could translate to potential candidates for future clinical practice.
Methodology.
A comprehensive review was conducted across three scientific literature databases spanning a 13-year period.
Results.
We identified 151 compounds with anti-
Candida
activity. Amongst these, 40 were reported with very strong inhibitory activity, having minimum inhibitory concentrations (MICs) against
Candida
spp. of <3.5 µg ml
−1
, 66 compounds were considered strong inhibitors and 45 compounds exhibited moderate inhibitory potential. From an analysis of the MICs, we deduced that the actinomycin-like compounds RSP01 and RSP02 were probably the most promising anti-
Candida
compounds. Other antifungals of note included filipin-like compounds, which demonstrated superior inhibition to amphotericin B and activity against
Candida glabrata
and
Candida krusei
, and bafilomycin derivatives, which had substantial inhibition against
Candida parapsilosis
.
Conclusion.
It is essential to recognize the limitations inherent in the quest for new antifungals, which encompass toxicity,
in vivo
effectiveness and constraints associated with limited data access. However, further investigation through in-depth study and emerging technologies is of paramount importance, given that there are still many more compounds to discover. This review highlights the importance of antifungal compounds derived from
Streptomyces
, which demonstrate robust inhibition, and, in many cases, low toxicity, making them promising candidates for the development of novel antifungal agents.</abstract><doi>10.1099/jmm.0.001777</doi><orcidid>https://orcid.org/0000-0001-8538-0636</orcidid><orcidid>https://orcid.org/0000-0003-0023-2621</orcidid><orcidid>https://orcid.org/0000-0001-6999-5585</orcidid><orcidid>https://orcid.org/0000-0002-4083-7855</orcidid><orcidid>https://orcid.org/0000-0001-5283-1541</orcidid><orcidid>https://orcid.org/0000-0002-0560-0115</orcidid></addata></record> |
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| source | Microbiology Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| title | Streptomyces: a natural source of anti-Candida agents: This article is part of the Candida collection |
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