New insights into establishment and maintenance of DNA methylation imprints in mammals

Fundamental to genomic imprinting in mammals is the acquisition of epigenetic marks that differ in male and female gametes at ‘imprinting control regions’ (ICRs). These marks mediate the allelic expression of imprinted genes in the offspring. Much has been learnt about the nature of imprint marks, t...

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Veröffentlicht in:	Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2013-01, Vol.368 (1609), p.20110336-20110336
Hauptverfasser:	Kelsey, Gavin, Feil, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry, Molecular Biology DNA Methylation Embryo, Mammalian - cytology Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Embryonic Development Epigenomics Female Fertilization Gene Expression Regulation, Developmental Genetic Loci Genomic Imprinting Germ Cells Histone Modifications Histones - genetics Histones - metabolism Life Sciences Male Mammals - embryology Mammals - genetics Oocytes - cytology Oocytes - metabolism Oogenesis Part II: Molecular mechanisms working in the mammalian life cycle Review RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Transcription, Genetic Zygote - cytology Zygote - metabolism
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