DNA methylation dynamics during the mammalian life cycle

DNA methylation is dynamically remodelled during the mammalian life cycle through distinct phases of reprogramming and de novo methylation. These events enable the acquisition of cellular potential followed by the maintenance of lineage-restricted cell identity, respectively, a process that defines...

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Veröffentlicht in:	Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2013-01, Vol.368 (1609), p.20110328-20110328
Hauptverfasser:	Hackett, Jamie A., Surani, M. Azim
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - metabolism Animals Bisulphite Cellular Reprogramming CpG Islands DNA Methylation Embryo, Mammalian - cytology Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Embryonic Development Epigenetics Gametogenesis Gene Expression Regulation, Developmental Genetic Loci Genomic Imprinting Genomic Instability Mammals - embryology Mammals - genetics Mammals - metabolism Part II: Molecular mechanisms working in the mammalian life cycle PGC Promoter Regions, Genetic Reprogramming Retroelements Review
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