CD4 Function in Thymocyte Differentiation and T Cell Activation

The ectodomains of the T cell surface glycoproteins CD4 and CD8 bind to membrane-proximal domains of MHC class II and class I molecules, respectively, while both cytoplasmic domains interact with the protein tyrosine kinase (PTK) p56$^{lck}$ (lck) through a shared cysteine-containing motif. Function...

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Veröffentlicht in:	Philosophical transactions of the Royal Society of London. Series B. Biological sciences 1993-10, Vol.342 (1299), p.25-34
Hauptverfasser:	Killeen, Nigel, Davis, Craig B., Chu, Keting, M. E. Casey Crooks, Sawada, Shinichiro, Scarborough, John D., Boyd, Kevin A., Stuart, Susan G., Xu, Hua, Littman, Dan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen presenting cells Biological and medical sciences CD4 Antigens - biosynthesis CD4 Antigens - metabolism CD4 Antigens - physiology CD8 Antigens - metabolism CD8 Antigens - physiology Cell Differentiation Cell lines Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation Histocompatibility Antigens Class I - metabolism Histocompatibility Antigens Class II - metabolism Humans Immunobiology Lymphocyte Activation Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Mice Molecular interactions Molecules Receptors Receptors, Antigen, T-Cell - physiology Signal Transduction T cell antigen receptors T lymphocytes T-Lymphocytes - cytology T-Lymphocytes - immunology Thymocytes Thymus Gland - cytology Thymus Gland - immunology Transgenic animals
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