Life or death: disease-tolerant coral species activate autophagy following immune challenge

Global climate change has increased the number and severity of stressors affecting species, yet not all species respond equally to these stressors. Organisms may employ cellular mechanisms such as apoptosis and autophagy in responding to stressful events. These two pathways are often mutually exclus...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Proceedings of the Royal Society. B, Biological sciences Biological sciences, 2017-06, Vol.284 (1856), p.20170771-20170771
Hauptverfasser: Fuess, Lauren E., Pinzón C, Jorge H., Weil, Ernesto, Grinshpon, Robert D., Mydlarz, Laura D.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 20170771
container_issue 1856
container_start_page 20170771
container_title Proceedings of the Royal Society. B, Biological sciences
container_volume 284
creator Fuess, Lauren E.
Pinzón C, Jorge H.
Weil, Ernesto
Grinshpon, Robert D.
Mydlarz, Laura D.
description Global climate change has increased the number and severity of stressors affecting species, yet not all species respond equally to these stressors. Organisms may employ cellular mechanisms such as apoptosis and autophagy in responding to stressful events. These two pathways are often mutually exclusive, dictating whether a cell adapts or dies. In order to examine differences in cellular response to stress, we compared the immune response of four coral species with a range of disease susceptibility. Using RNA-seq and novel pathway analysis, we were able to identify differences in response to immune stimulation between these species. Disease-susceptible species Orbicella faveolata activated pathways associated with apoptosis. By contrast, disease-tolerant species Porites porites and Porites astreoides activated autophagic pathways. Moderately susceptible species Pseudodiploria strigosa activated a mixture of these pathways. These findings were corroborated by apoptotic caspase protein assays, which indicated increased caspase activity following immune stimulation in susceptible species. Our results indicate that in response to immune stress, disease-tolerant species activate cellular adaptive mechanisms such as autophagy, while susceptible species turn on cell death pathways. Differences in these cellular maintenance pathways may therefore influence the organismal stress response. Further study of these pathways will increase understanding of differential stress response and species survival in the face of changing environments.
doi_str_mv 10.1098/rspb.2017.0771
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1098_rspb_2017_0771</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1907321621</sourcerecordid><originalsourceid>FETCH-LOGICAL-c628t-3dc8e927e28bcb9c2a44e7735437ea190947909dbce991ae6a63dc941652c5533</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhSMEotPCliWKxIZNBj9jmwUSVOUhjQTisWJhOc6dGZckTm1n0PDrcZihaivBxnfh75x7rk5RPMFoiZGSL0IcmyVBWCyREPhescBM4Ioozu4XC6RqUknGyUlxGuMlQkhxyR8WJ0RyRWpRL4rvK7eG0oeyBZO2L8vWRTARquQ7CGZIpfXBdGUcwTqIpbHJ7UyC0kzJj1uz2Zdr33X-pxs2pev7aYDSbk3XwbCBR8WDtekiPD7Os-Lb24uv5--r1cd3H85frypbE5kq2loJigggsrGNssQwBkJQzqgAgxVSTOSnbSwohQ3Ups4SxXDNieWc0rPi1cF3nJoeWgtDypn1GFxvwl574_Ttn8Ft9cbvNGeCIYmzwfOjQfBXE8SkexctdJ0ZwE9R5wyCElyTGX12B730UxjyeZmSVNFaMpap5YGywccYYH0dBiM996bn3vTcm557y4KnN0-4xv8WlQF6AILf52U-t5H2N3b_y_bH_1Sfv3x6syOSOSx5rZGkGAmmKNG_3Hi0kky7GCfQf5Db9ne3_QZLOMnT</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1983936844</pqid></control><display><type>article</type><title>Life or death: disease-tolerant coral species activate autophagy following immune challenge</title><source>MEDLINE</source><source>Jstor Complete Legacy</source><source>PubMed Central</source><creator>Fuess, Lauren E. ; Pinzón C, Jorge H. ; Weil, Ernesto ; Grinshpon, Robert D. ; Mydlarz, Laura D.</creator><creatorcontrib>Fuess, Lauren E. ; Pinzón C, Jorge H. ; Weil, Ernesto ; Grinshpon, Robert D. ; Mydlarz, Laura D.</creatorcontrib><description>Global climate change has increased the number and severity of stressors affecting species, yet not all species respond equally to these stressors. Organisms may employ cellular mechanisms such as apoptosis and autophagy in responding to stressful events. These two pathways are often mutually exclusive, dictating whether a cell adapts or dies. In order to examine differences in cellular response to stress, we compared the immune response of four coral species with a range of disease susceptibility. Using RNA-seq and novel pathway analysis, we were able to identify differences in response to immune stimulation between these species. Disease-susceptible species Orbicella faveolata activated pathways associated with apoptosis. By contrast, disease-tolerant species Porites porites and Porites astreoides activated autophagic pathways. Moderately susceptible species Pseudodiploria strigosa activated a mixture of these pathways. These findings were corroborated by apoptotic caspase protein assays, which indicated increased caspase activity following immune stimulation in susceptible species. Our results indicate that in response to immune stress, disease-tolerant species activate cellular adaptive mechanisms such as autophagy, while susceptible species turn on cell death pathways. Differences in these cellular maintenance pathways may therefore influence the organismal stress response. Further study of these pathways will increase understanding of differential stress response and species survival in the face of changing environments.</description><edition>Royal Society (Great Britain)</edition><identifier>ISSN: 0962-8452</identifier><identifier>EISSN: 1471-2954</identifier><identifier>DOI: 10.1098/rspb.2017.0771</identifier><identifier>PMID: 28592676</identifier><language>eng</language><publisher>England: The Royal Society</publisher><subject>Animals ; Anthozoa - immunology ; Apoptosis ; Autophagy ; Caspase ; Cell Death ; Cellular stress response ; Changing environments ; Climate Change ; Coral ; Disease Resistance - immunology ; Ecology ; Immune response ; Immune system ; Immunity ; Phagocytosis ; Ribonucleic acid ; RNA ; Species ; Stimulation ; Stress response ; Stresses</subject><ispartof>Proceedings of the Royal Society. B, Biological sciences, 2017-06, Vol.284 (1856), p.20170771-20170771</ispartof><rights>2017 The Author(s)</rights><rights>2017 The Author(s).</rights><rights>Copyright The Royal Society Publishing Jun 14, 2017</rights><rights>2017 The Author(s) 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c628t-3dc8e927e28bcb9c2a44e7735437ea190947909dbce991ae6a63dc941652c5533</citedby><cites>FETCH-LOGICAL-c628t-3dc8e927e28bcb9c2a44e7735437ea190947909dbce991ae6a63dc941652c5533</cites><orcidid>0000-0003-0197-7326</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474081/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474081/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28592676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuess, Lauren E.</creatorcontrib><creatorcontrib>Pinzón C, Jorge H.</creatorcontrib><creatorcontrib>Weil, Ernesto</creatorcontrib><creatorcontrib>Grinshpon, Robert D.</creatorcontrib><creatorcontrib>Mydlarz, Laura D.</creatorcontrib><title>Life or death: disease-tolerant coral species activate autophagy following immune challenge</title><title>Proceedings of the Royal Society. B, Biological sciences</title><addtitle>Proc. R. Soc. B</addtitle><addtitle>Proc Biol Sci</addtitle><description>Global climate change has increased the number and severity of stressors affecting species, yet not all species respond equally to these stressors. Organisms may employ cellular mechanisms such as apoptosis and autophagy in responding to stressful events. These two pathways are often mutually exclusive, dictating whether a cell adapts or dies. In order to examine differences in cellular response to stress, we compared the immune response of four coral species with a range of disease susceptibility. Using RNA-seq and novel pathway analysis, we were able to identify differences in response to immune stimulation between these species. Disease-susceptible species Orbicella faveolata activated pathways associated with apoptosis. By contrast, disease-tolerant species Porites porites and Porites astreoides activated autophagic pathways. Moderately susceptible species Pseudodiploria strigosa activated a mixture of these pathways. These findings were corroborated by apoptotic caspase protein assays, which indicated increased caspase activity following immune stimulation in susceptible species. Our results indicate that in response to immune stress, disease-tolerant species activate cellular adaptive mechanisms such as autophagy, while susceptible species turn on cell death pathways. Differences in these cellular maintenance pathways may therefore influence the organismal stress response. Further study of these pathways will increase understanding of differential stress response and species survival in the face of changing environments.</description><subject>Animals</subject><subject>Anthozoa - immunology</subject><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Caspase</subject><subject>Cell Death</subject><subject>Cellular stress response</subject><subject>Changing environments</subject><subject>Climate Change</subject><subject>Coral</subject><subject>Disease Resistance - immunology</subject><subject>Ecology</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Phagocytosis</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Species</subject><subject>Stimulation</subject><subject>Stress response</subject><subject>Stresses</subject><issn>0962-8452</issn><issn>1471-2954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAUhSMEotPCliWKxIZNBj9jmwUSVOUhjQTisWJhOc6dGZckTm1n0PDrcZihaivBxnfh75x7rk5RPMFoiZGSL0IcmyVBWCyREPhescBM4Ioozu4XC6RqUknGyUlxGuMlQkhxyR8WJ0RyRWpRL4rvK7eG0oeyBZO2L8vWRTARquQ7CGZIpfXBdGUcwTqIpbHJ7UyC0kzJj1uz2Zdr33X-pxs2pev7aYDSbk3XwbCBR8WDtekiPD7Os-Lb24uv5--r1cd3H85frypbE5kq2loJigggsrGNssQwBkJQzqgAgxVSTOSnbSwohQ3Ups4SxXDNieWc0rPi1cF3nJoeWgtDypn1GFxvwl574_Ttn8Ft9cbvNGeCIYmzwfOjQfBXE8SkexctdJ0ZwE9R5wyCElyTGX12B730UxjyeZmSVNFaMpap5YGywccYYH0dBiM996bn3vTcm557y4KnN0-4xv8WlQF6AILf52U-t5H2N3b_y_bH_1Sfv3x6syOSOSx5rZGkGAmmKNG_3Hi0kky7GCfQf5Db9ne3_QZLOMnT</recordid><startdate>20170614</startdate><enddate>20170614</enddate><creator>Fuess, Lauren E.</creator><creator>Pinzón C, Jorge H.</creator><creator>Weil, Ernesto</creator><creator>Grinshpon, Robert D.</creator><creator>Mydlarz, Laura D.</creator><general>The Royal Society</general><general>The Royal Society Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0197-7326</orcidid></search><sort><creationdate>20170614</creationdate><title>Life or death: disease-tolerant coral species activate autophagy following immune challenge</title><author>Fuess, Lauren E. ; Pinzón C, Jorge H. ; Weil, Ernesto ; Grinshpon, Robert D. ; Mydlarz, Laura D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c628t-3dc8e927e28bcb9c2a44e7735437ea190947909dbce991ae6a63dc941652c5533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Anthozoa - immunology</topic><topic>Apoptosis</topic><topic>Autophagy</topic><topic>Caspase</topic><topic>Cell Death</topic><topic>Cellular stress response</topic><topic>Changing environments</topic><topic>Climate Change</topic><topic>Coral</topic><topic>Disease Resistance - immunology</topic><topic>Ecology</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Phagocytosis</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Species</topic><topic>Stimulation</topic><topic>Stress response</topic><topic>Stresses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuess, Lauren E.</creatorcontrib><creatorcontrib>Pinzón C, Jorge H.</creatorcontrib><creatorcontrib>Weil, Ernesto</creatorcontrib><creatorcontrib>Grinshpon, Robert D.</creatorcontrib><creatorcontrib>Mydlarz, Laura D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuess, Lauren E.</au><au>Pinzón C, Jorge H.</au><au>Weil, Ernesto</au><au>Grinshpon, Robert D.</au><au>Mydlarz, Laura D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Life or death: disease-tolerant coral species activate autophagy following immune challenge</atitle><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle><stitle>Proc. R. Soc. B</stitle><addtitle>Proc Biol Sci</addtitle><date>2017-06-14</date><risdate>2017</risdate><volume>284</volume><issue>1856</issue><spage>20170771</spage><epage>20170771</epage><pages>20170771-20170771</pages><issn>0962-8452</issn><eissn>1471-2954</eissn><abstract>Global climate change has increased the number and severity of stressors affecting species, yet not all species respond equally to these stressors. Organisms may employ cellular mechanisms such as apoptosis and autophagy in responding to stressful events. These two pathways are often mutually exclusive, dictating whether a cell adapts or dies. In order to examine differences in cellular response to stress, we compared the immune response of four coral species with a range of disease susceptibility. Using RNA-seq and novel pathway analysis, we were able to identify differences in response to immune stimulation between these species. Disease-susceptible species Orbicella faveolata activated pathways associated with apoptosis. By contrast, disease-tolerant species Porites porites and Porites astreoides activated autophagic pathways. Moderately susceptible species Pseudodiploria strigosa activated a mixture of these pathways. These findings were corroborated by apoptotic caspase protein assays, which indicated increased caspase activity following immune stimulation in susceptible species. Our results indicate that in response to immune stress, disease-tolerant species activate cellular adaptive mechanisms such as autophagy, while susceptible species turn on cell death pathways. Differences in these cellular maintenance pathways may therefore influence the organismal stress response. Further study of these pathways will increase understanding of differential stress response and species survival in the face of changing environments.</abstract><cop>England</cop><pub>The Royal Society</pub><pmid>28592676</pmid><doi>10.1098/rspb.2017.0771</doi><tpages>1</tpages><edition>Royal Society (Great Britain)</edition><orcidid>https://orcid.org/0000-0003-0197-7326</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0962-8452
ispartof Proceedings of the Royal Society. B, Biological sciences, 2017-06, Vol.284 (1856), p.20170771-20170771
issn 0962-8452
1471-2954
language eng
recordid cdi_crossref_primary_10_1098_rspb_2017_0771
source MEDLINE; Jstor Complete Legacy; PubMed Central
subjects Animals
Anthozoa - immunology
Apoptosis
Autophagy
Caspase
Cell Death
Cellular stress response
Changing environments
Climate Change
Coral
Disease Resistance - immunology
Ecology
Immune response
Immune system
Immunity
Phagocytosis
Ribonucleic acid
RNA
Species
Stimulation
Stress response
Stresses
title Life or death: disease-tolerant coral species activate autophagy following immune challenge
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T01%3A39%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Life%20or%20death:%20disease-tolerant%20coral%20species%20activate%20autophagy%20following%20immune%20challenge&rft.jtitle=Proceedings%20of%20the%20Royal%20Society.%20B,%20Biological%20sciences&rft.au=Fuess,%20Lauren%20E.&rft.date=2017-06-14&rft.volume=284&rft.issue=1856&rft.spage=20170771&rft.epage=20170771&rft.pages=20170771-20170771&rft.issn=0962-8452&rft.eissn=1471-2954&rft_id=info:doi/10.1098/rspb.2017.0771&rft_dat=%3Cproquest_cross%3E1907321621%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1983936844&rft_id=info:pmid/28592676&rfr_iscdi=true