Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations
Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the...
Gespeichert in:
| Veröffentlicht in: | Biology letters (2005) 2013-02, Vol.9 (1), p.20121049-20121049 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 20121049 |
|---|---|
| container_issue | 1 |
| container_start_page | 20121049 |
| container_title | Biology letters (2005) |
| container_volume | 9 |
| creator | Komarova, Natalia L. Anghelina, Daniela Voznesensky, Igor Trinité, Benjamin Levy, David N. Wodarz, Dominik |
| description | Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population. |
| doi_str_mv | 10.1098/rsbl.2012.1049 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1098_rsbl_2012_1049</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1273427518</sourcerecordid><originalsourceid>FETCH-LOGICAL-c661t-19956bc351d62a7aeaa1bc2182519913380e94df80e61666070a9c133e899d303</originalsourceid><addsrcrecordid>eNqFUk2P0zAQjRCIXRauHJGPXFI8dmzHFyRYUXalAqLAipvlJE7rJY2ztlNRfj2OslR8CDiNPfPmzTw_Z9ljwAvAsnzmQ9UtCAaSroW8k52CKIpcMvH57vHM4SR7EMI1xlQIzO5nJ4QSLsuiOM3i2nQ62r1Bteujt9UYreuRa1Hrjcn31o8B6b5B4dDrIdoaRa_7sLMhTLjoUNwaFAZvdDN1XVxe5ZBy3o2bLYrab0xEtek6NLhhnEa5PjzM7rW6C-bRbTzLPi1ffTy_yFfvXl-ev1jlNecQc5Bp96qmDBpOtNBGa6hqAiVhqQSUltjIomlT4MA5xwJrWae8KaVsKKZn2fOZdxirnWlqkxTqTg3e7rQ_KKet-rXS263auL2ijDNGykTw9JbAu5vRhKiS8EmN7o0bgwLGgBdUlvz_UCJoQQSDiXUxQ2vvQvCmPW4EWE2uqslVNbmqJldTw5OfdRzhP2xMADoDvDukB3W1NfGgrt3o-3T9O63-V9f6w8vVXlpQuKSABSG4UN_sMLNIlX7AaBT8RvrnjHyeYUM0X4-ba_9FcUEFU1dlod6u3yxBvl-qkn4He6zg0g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1273427518</pqid></control><display><type>article</type><title>Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Komarova, Natalia L. ; Anghelina, Daniela ; Voznesensky, Igor ; Trinité, Benjamin ; Levy, David N. ; Wodarz, Dominik</creator><creatorcontrib>Komarova, Natalia L. ; Anghelina, Daniela ; Voznesensky, Igor ; Trinité, Benjamin ; Levy, David N. ; Wodarz, Dominik</creatorcontrib><description>Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population.</description><identifier>ISSN: 1744-9561</identifier><identifier>EISSN: 1744-957X</identifier><identifier>DOI: 10.1098/rsbl.2012.1049</identifier><identifier>PMID: 23269844</identifier><language>eng</language><publisher>England: The Royal Society</publisher><subject>CD4-Positive T-Lymphocytes - virology ; Flow Cytometry ; HIV Infections - transmission ; HIV Infections - virology ; HIV-1 - growth & development ; Human Immunodeficiency Virus ; Human immunodeficiency virus 1 ; Humans ; Jurkat Cells ; Mathematical Model ; Models, Biological ; Population Ecology ; Virion - metabolism ; Virological Synapse ; Virus Replication</subject><ispartof>Biology letters (2005), 2013-02, Vol.9 (1), p.20121049-20121049</ispartof><rights>2012 The Author(s) Published by the Royal Society. All rights reserved.</rights><rights>2012 The Author(s) Published by the Royal Society. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c661t-19956bc351d62a7aeaa1bc2182519913380e94df80e61666070a9c133e899d303</citedby><cites>FETCH-LOGICAL-c661t-19956bc351d62a7aeaa1bc2182519913380e94df80e61666070a9c133e899d303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565528/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565528/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23269844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Komarova, Natalia L.</creatorcontrib><creatorcontrib>Anghelina, Daniela</creatorcontrib><creatorcontrib>Voznesensky, Igor</creatorcontrib><creatorcontrib>Trinité, Benjamin</creatorcontrib><creatorcontrib>Levy, David N.</creatorcontrib><creatorcontrib>Wodarz, Dominik</creatorcontrib><title>Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations</title><title>Biology letters (2005)</title><addtitle>Biol. Lett</addtitle><addtitle>Biol. Lett</addtitle><description>Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population.</description><subject>CD4-Positive T-Lymphocytes - virology</subject><subject>Flow Cytometry</subject><subject>HIV Infections - transmission</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - growth & development</subject><subject>Human Immunodeficiency Virus</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Jurkat Cells</subject><subject>Mathematical Model</subject><subject>Models, Biological</subject><subject>Population Ecology</subject><subject>Virion - metabolism</subject><subject>Virological Synapse</subject><subject>Virus Replication</subject><issn>1744-9561</issn><issn>1744-957X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk2P0zAQjRCIXRauHJGPXFI8dmzHFyRYUXalAqLAipvlJE7rJY2ztlNRfj2OslR8CDiNPfPmzTw_Z9ljwAvAsnzmQ9UtCAaSroW8k52CKIpcMvH57vHM4SR7EMI1xlQIzO5nJ4QSLsuiOM3i2nQ62r1Bteujt9UYreuRa1Hrjcn31o8B6b5B4dDrIdoaRa_7sLMhTLjoUNwaFAZvdDN1XVxe5ZBy3o2bLYrab0xEtek6NLhhnEa5PjzM7rW6C-bRbTzLPi1ffTy_yFfvXl-ev1jlNecQc5Bp96qmDBpOtNBGa6hqAiVhqQSUltjIomlT4MA5xwJrWae8KaVsKKZn2fOZdxirnWlqkxTqTg3e7rQ_KKet-rXS263auL2ijDNGykTw9JbAu5vRhKiS8EmN7o0bgwLGgBdUlvz_UCJoQQSDiXUxQ2vvQvCmPW4EWE2uqslVNbmqJldTw5OfdRzhP2xMADoDvDukB3W1NfGgrt3o-3T9O63-V9f6w8vVXlpQuKSABSG4UN_sMLNIlX7AaBT8RvrnjHyeYUM0X4-ba_9FcUEFU1dlod6u3yxBvl-qkn4He6zg0g</recordid><startdate>20130223</startdate><enddate>20130223</enddate><creator>Komarova, Natalia L.</creator><creator>Anghelina, Daniela</creator><creator>Voznesensky, Igor</creator><creator>Trinité, Benjamin</creator><creator>Levy, David N.</creator><creator>Wodarz, Dominik</creator><general>The Royal Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20130223</creationdate><title>Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations</title><author>Komarova, Natalia L. ; Anghelina, Daniela ; Voznesensky, Igor ; Trinité, Benjamin ; Levy, David N. ; Wodarz, Dominik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c661t-19956bc351d62a7aeaa1bc2182519913380e94df80e61666070a9c133e899d303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>CD4-Positive T-Lymphocytes - virology</topic><topic>Flow Cytometry</topic><topic>HIV Infections - transmission</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - growth & development</topic><topic>Human Immunodeficiency Virus</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Jurkat Cells</topic><topic>Mathematical Model</topic><topic>Models, Biological</topic><topic>Population Ecology</topic><topic>Virion - metabolism</topic><topic>Virological Synapse</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Komarova, Natalia L.</creatorcontrib><creatorcontrib>Anghelina, Daniela</creatorcontrib><creatorcontrib>Voznesensky, Igor</creatorcontrib><creatorcontrib>Trinité, Benjamin</creatorcontrib><creatorcontrib>Levy, David N.</creatorcontrib><creatorcontrib>Wodarz, Dominik</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biology letters (2005)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Komarova, Natalia L.</au><au>Anghelina, Daniela</au><au>Voznesensky, Igor</au><au>Trinité, Benjamin</au><au>Levy, David N.</au><au>Wodarz, Dominik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations</atitle><jtitle>Biology letters (2005)</jtitle><stitle>Biol. Lett</stitle><addtitle>Biol. Lett</addtitle><date>2013-02-23</date><risdate>2013</risdate><volume>9</volume><issue>1</issue><spage>20121049</spage><epage>20121049</epage><pages>20121049-20121049</pages><issn>1744-9561</issn><eissn>1744-957X</eissn><abstract>Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population.</abstract><cop>England</cop><pub>The Royal Society</pub><pmid>23269844</pmid><doi>10.1098/rsbl.2012.1049</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1744-9561 |
| ispartof | Biology letters (2005), 2013-02, Vol.9 (1), p.20121049-20121049 |
| issn | 1744-9561 1744-957X |
| language | eng |
| recordid | cdi_crossref_primary_10_1098_rsbl_2012_1049 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | CD4-Positive T-Lymphocytes - virology Flow Cytometry HIV Infections - transmission HIV Infections - virology HIV-1 - growth & development Human Immunodeficiency Virus Human immunodeficiency virus 1 Humans Jurkat Cells Mathematical Model Models, Biological Population Ecology Virion - metabolism Virological Synapse Virus Replication |
| title | Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T20%3A27%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relative%20contribution%20of%20free-virus%20and%20synaptic%20transmission%20to%20the%20spread%20of%20HIV-1%20through%20target%20cell%20populations&rft.jtitle=Biology%20letters%20(2005)&rft.au=Komarova,%20Natalia%20L.&rft.date=2013-02-23&rft.volume=9&rft.issue=1&rft.spage=20121049&rft.epage=20121049&rft.pages=20121049-20121049&rft.issn=1744-9561&rft.eissn=1744-957X&rft_id=info:doi/10.1098/rsbl.2012.1049&rft_dat=%3Cproquest_cross%3E1273427518%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1273427518&rft_id=info:pmid/23269844&rfr_iscdi=true |