Photodynamic therapy for pancreatic cancer
This study examined the status of photodynamic therapy (PDT) in the treatment of cancers of the pancreas. Original and review articles, editorials, and case reports published primarily in English and listed in Medline/ISI up to October 2006 or identified by a manual search have been reviewed in an a...
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| Veröffentlicht in: | PANCREAS 2007-05, Vol.34 (4), p.385-389 |
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| container_title | PANCREAS |
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| creator | Fan, Bo-Guang Andrén-Sandberg, Ake |
| description | This study examined the status of photodynamic therapy (PDT) in the treatment of cancers of the pancreas.
Original and review articles, editorials, and case reports published primarily in English and listed in Medline/ISI up to October 2006 or identified by a manual search have been reviewed in an attempt to provide a comprehensive overview of the mechanisms of PDT action and clinical application of PDT in the treatment of pancreatic cancers.
Photodynamic therapy represents a novel treatment of pancreatic malignancy; it produces local necrosis of tissue with light after administration of a photosensitizing agent. Evidences from in vivo and in vitro results have shown that PDT significantly decreases pancreatic cancer cell growth, destroys pancreatic carcinoma, and prolongs the survival of patients with unresectable pancreatic malignancy, and also show that PDT has disadvantages and limitations for the treatment of pancreatic cancer.
Photodynamic therapy can be an effective treatment of patients with pancreatic cancer, but more extensive preclinical and clinical trials are needed for further improvement in the clinical application of PDT, especially in avoidance of complications during PDT. |
| doi_str_mv | 10.1097/mpa.0b013e3180439c50 |
| format | Article |
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Original and review articles, editorials, and case reports published primarily in English and listed in Medline/ISI up to October 2006 or identified by a manual search have been reviewed in an attempt to provide a comprehensive overview of the mechanisms of PDT action and clinical application of PDT in the treatment of pancreatic cancers.
Photodynamic therapy represents a novel treatment of pancreatic malignancy; it produces local necrosis of tissue with light after administration of a photosensitizing agent. Evidences from in vivo and in vitro results have shown that PDT significantly decreases pancreatic cancer cell growth, destroys pancreatic carcinoma, and prolongs the survival of patients with unresectable pancreatic malignancy, and also show that PDT has disadvantages and limitations for the treatment of pancreatic cancer.
Photodynamic therapy can be an effective treatment of patients with pancreatic cancer, but more extensive preclinical and clinical trials are needed for further improvement in the clinical application of PDT, especially in avoidance of complications during PDT.</description><identifier>ISSN: 0885-3177</identifier><identifier>EISSN: 1536-4828</identifier><identifier>DOI: 10.1097/mpa.0b013e3180439c50</identifier><identifier>PMID: 17446835</identifier><language>eng</language><publisher>United States</publisher><subject>Adenocarcinoma - drug therapy ; Adenocarcinoma - pathology ; Animals ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - therapeutic use ; Humans ; Necrosis ; Pancreas - drug effects ; Pancreas - pathology ; Pancreatic Neoplasms - drug therapy ; Pancreatic Neoplasms - pathology ; Photochemotherapy - adverse effects ; Photochemotherapy - methods ; Photosensitizing Agents - adverse effects ; Photosensitizing Agents - therapeutic use ; Treatment Outcome</subject><ispartof>PANCREAS, 2007-05, Vol.34 (4), p.385-389</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-ba512a436fb756ddd8716721d043db42f3097b1c97575d8d451381b269dcc8cd3</citedby><cites>FETCH-LOGICAL-c343t-ba512a436fb756ddd8716721d043db42f3097b1c97575d8d451381b269dcc8cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17446835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:115427827$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, Bo-Guang</creatorcontrib><creatorcontrib>Andrén-Sandberg, Ake</creatorcontrib><title>Photodynamic therapy for pancreatic cancer</title><title>PANCREAS</title><addtitle>Pancreas</addtitle><description>This study examined the status of photodynamic therapy (PDT) in the treatment of cancers of the pancreas.
Original and review articles, editorials, and case reports published primarily in English and listed in Medline/ISI up to October 2006 or identified by a manual search have been reviewed in an attempt to provide a comprehensive overview of the mechanisms of PDT action and clinical application of PDT in the treatment of pancreatic cancers.
Photodynamic therapy represents a novel treatment of pancreatic malignancy; it produces local necrosis of tissue with light after administration of a photosensitizing agent. Evidences from in vivo and in vitro results have shown that PDT significantly decreases pancreatic cancer cell growth, destroys pancreatic carcinoma, and prolongs the survival of patients with unresectable pancreatic malignancy, and also show that PDT has disadvantages and limitations for the treatment of pancreatic cancer.
Photodynamic therapy can be an effective treatment of patients with pancreatic cancer, but more extensive preclinical and clinical trials are needed for further improvement in the clinical application of PDT, especially in avoidance of complications during PDT.</description><subject>Adenocarcinoma - drug therapy</subject><subject>Adenocarcinoma - pathology</subject><subject>Animals</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Humans</subject><subject>Necrosis</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - pathology</subject><subject>Pancreatic Neoplasms - drug therapy</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Photochemotherapy - adverse effects</subject><subject>Photochemotherapy - methods</subject><subject>Photosensitizing Agents - adverse effects</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0885-3177</issn><issn>1536-4828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLxEAQhAdR3HX1H4jkLGSdTs8rR1lcFRb0oOdhXmGjZhMmEcm_dyRBwVMXTVVRfIRcAl0DLeVN05k1tRQwICjKsHScHpElcBQ5U4U6JkuqFM8RpFyQs75_oxQk8vKULEAyJhTyJbl-3rdD68eDaWqXDfsQTTdmVRuzzhxcDGZIb5dkiOfkpDIffbiY74q8bu9eNg_57un-cXO7yx0yHHJrOBSGoais5MJ7ryQIWYBPG71lRYVpvQVXSi65V55xQAW2EKV3TjmPK5JPvf1X6D6t7mLdmDjq1tR6fr0nFTSXlIsi-dnkd7Ht-xiq3wRQ_YNKJ1T6P6oUu5piqbAJ_i80s8Fv7uhlsg</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Fan, Bo-Guang</creator><creator>Andrén-Sandberg, Ake</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20070501</creationdate><title>Photodynamic therapy for pancreatic cancer</title><author>Fan, Bo-Guang ; Andrén-Sandberg, Ake</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-ba512a436fb756ddd8716721d043db42f3097b1c97575d8d451381b269dcc8cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenocarcinoma - drug therapy</topic><topic>Adenocarcinoma - pathology</topic><topic>Animals</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Humans</topic><topic>Necrosis</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - pathology</topic><topic>Pancreatic Neoplasms - drug therapy</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Photochemotherapy - adverse effects</topic><topic>Photochemotherapy - methods</topic><topic>Photosensitizing Agents - adverse effects</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fan, Bo-Guang</creatorcontrib><creatorcontrib>Andrén-Sandberg, Ake</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>PANCREAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fan, Bo-Guang</au><au>Andrén-Sandberg, Ake</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photodynamic therapy for pancreatic cancer</atitle><jtitle>PANCREAS</jtitle><addtitle>Pancreas</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>34</volume><issue>4</issue><spage>385</spage><epage>389</epage><pages>385-389</pages><issn>0885-3177</issn><eissn>1536-4828</eissn><abstract>This study examined the status of photodynamic therapy (PDT) in the treatment of cancers of the pancreas.
Original and review articles, editorials, and case reports published primarily in English and listed in Medline/ISI up to October 2006 or identified by a manual search have been reviewed in an attempt to provide a comprehensive overview of the mechanisms of PDT action and clinical application of PDT in the treatment of pancreatic cancers.
Photodynamic therapy represents a novel treatment of pancreatic malignancy; it produces local necrosis of tissue with light after administration of a photosensitizing agent. Evidences from in vivo and in vitro results have shown that PDT significantly decreases pancreatic cancer cell growth, destroys pancreatic carcinoma, and prolongs the survival of patients with unresectable pancreatic malignancy, and also show that PDT has disadvantages and limitations for the treatment of pancreatic cancer.
Photodynamic therapy can be an effective treatment of patients with pancreatic cancer, but more extensive preclinical and clinical trials are needed for further improvement in the clinical application of PDT, especially in avoidance of complications during PDT.</abstract><cop>United States</cop><pmid>17446835</pmid><doi>10.1097/mpa.0b013e3180439c50</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0885-3177 |
| ispartof | PANCREAS, 2007-05, Vol.34 (4), p.385-389 |
| issn | 0885-3177 1536-4828 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adenocarcinoma - drug therapy Adenocarcinoma - pathology Animals Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Humans Necrosis Pancreas - drug effects Pancreas - pathology Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Photochemotherapy - adverse effects Photochemotherapy - methods Photosensitizing Agents - adverse effects Photosensitizing Agents - therapeutic use Treatment Outcome |
| title | Photodynamic therapy for pancreatic cancer |
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