Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity
The counterirritation phenomenon known as conditioned pain modulation, or diffuse noxious inhibitory control in animals, is of increasing interest due to its utility in predicting chronic pain and treatment response. It features considerable interindividual variability, with large subsets of pain pa...
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Veröffentlicht in: | Pain (Amsterdam) 2019-04, Vol.160 (4), p.784-792 |
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creator | Tansley, Shannon N. Macintyre, Leigh C. Diamond, Laura Sotocinal, Susana G. George, Nicole Meluban, Lee Austin, Jean-Sebastien Coderre, Terence J. Martin, Loren J. Mogil, Jeffrey S. |
description | The counterirritation phenomenon known as conditioned pain modulation, or diffuse noxious inhibitory control in animals, is of increasing interest due to its utility in predicting chronic pain and treatment response. It features considerable interindividual variability, with large subsets of pain patients and even normal volunteers exhibiting hyperalgesia rather than hypoalgesia during or immediately after receiving a conditioning stimulus. We observed that mice undergoing tonic inflammatory pain in the abdominal cavity (the conditioning stimulus) display hyperalgesia, not hypoalgesia, to noxious thermal stimulation (the test stimulus) applied to the hindpaw. In a series of parametric studies, we show that this hyperalgesia can be reliably observed using multiple conditioning stimuli (acetic acid and orofacial formalin), test stimuli (hindpaw and forepaw-withdrawal, tail-withdrawal, hot-plate, and von Frey tests) and genotypes (CD-1, DBA/2, and C57BL/6 mice and Sprague-Dawley rats). Although the magnitude of the hyperalgesia is dependent on the intensity of the conditioning stimulus, we find that the direction of effect is dependent on the effective test stimulus intensity, with lower-intensity stimuli leading to hyperalgesia and higher-intensity stimuli leading to hypoalgesia. |
doi_str_mv | 10.1097/j.pain.0000000000001454 |
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It features considerable interindividual variability, with large subsets of pain patients and even normal volunteers exhibiting hyperalgesia rather than hypoalgesia during or immediately after receiving a conditioning stimulus. We observed that mice undergoing tonic inflammatory pain in the abdominal cavity (the conditioning stimulus) display hyperalgesia, not hypoalgesia, to noxious thermal stimulation (the test stimulus) applied to the hindpaw. In a series of parametric studies, we show that this hyperalgesia can be reliably observed using multiple conditioning stimuli (acetic acid and orofacial formalin), test stimuli (hindpaw and forepaw-withdrawal, tail-withdrawal, hot-plate, and von Frey tests) and genotypes (CD-1, DBA/2, and C57BL/6 mice and Sprague-Dawley rats). Although the magnitude of the hyperalgesia is dependent on the intensity of the conditioning stimulus, we find that the direction of effect is dependent on the effective test stimulus intensity, with lower-intensity stimuli leading to hyperalgesia and higher-intensity stimuli leading to hypoalgesia.</description><identifier>ISSN: 0304-3959</identifier><identifier>EISSN: 1872-6623</identifier><identifier>DOI: 10.1097/j.pain.0000000000001454</identifier><identifier>PMID: 30681982</identifier><language>eng</language><publisher>United States: Wolters Kluwer</publisher><subject>Acetic Acid - toxicity ; Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Facial Pain - complications ; Formaldehyde - toxicity ; Hyperalgesia - etiology ; Hypesthesia - etiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Pain - complications ; Pain - etiology ; Pain Measurement ; Peripheral Nerve Injuries - complications ; Physical Stimulation - adverse effects ; Psychophysics ; Rats ; Rats, Sprague-Dawley ; Species Specificity</subject><ispartof>Pain (Amsterdam), 2019-04, Vol.160 (4), p.784-792</ispartof><rights>Wolters Kluwer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3584-870340b6629961945b36beb506bd0670f78d8091f9d5f53748f0997a97e233913</citedby><cites>FETCH-LOGICAL-c3584-870340b6629961945b36beb506bd0670f78d8091f9d5f53748f0997a97e233913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30681982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tansley, Shannon N.</creatorcontrib><creatorcontrib>Macintyre, Leigh C.</creatorcontrib><creatorcontrib>Diamond, Laura</creatorcontrib><creatorcontrib>Sotocinal, Susana G.</creatorcontrib><creatorcontrib>George, Nicole</creatorcontrib><creatorcontrib>Meluban, Lee</creatorcontrib><creatorcontrib>Austin, Jean-Sebastien</creatorcontrib><creatorcontrib>Coderre, Terence J.</creatorcontrib><creatorcontrib>Martin, Loren J.</creatorcontrib><creatorcontrib>Mogil, Jeffrey S.</creatorcontrib><title>Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity</title><title>Pain (Amsterdam)</title><addtitle>Pain</addtitle><description>The counterirritation phenomenon known as conditioned pain modulation, or diffuse noxious inhibitory control in animals, is of increasing interest due to its utility in predicting chronic pain and treatment response. It features considerable interindividual variability, with large subsets of pain patients and even normal volunteers exhibiting hyperalgesia rather than hypoalgesia during or immediately after receiving a conditioning stimulus. We observed that mice undergoing tonic inflammatory pain in the abdominal cavity (the conditioning stimulus) display hyperalgesia, not hypoalgesia, to noxious thermal stimulation (the test stimulus) applied to the hindpaw. In a series of parametric studies, we show that this hyperalgesia can be reliably observed using multiple conditioning stimuli (acetic acid and orofacial formalin), test stimuli (hindpaw and forepaw-withdrawal, tail-withdrawal, hot-plate, and von Frey tests) and genotypes (CD-1, DBA/2, and C57BL/6 mice and Sprague-Dawley rats). Although the magnitude of the hyperalgesia is dependent on the intensity of the conditioning stimulus, we find that the direction of effect is dependent on the effective test stimulus intensity, with lower-intensity stimuli leading to hyperalgesia and higher-intensity stimuli leading to hypoalgesia.</description><subject>Acetic Acid - toxicity</subject><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Facial Pain - complications</subject><subject>Formaldehyde - toxicity</subject><subject>Hyperalgesia - etiology</subject><subject>Hypesthesia - etiology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred DBA</subject><subject>Pain - complications</subject><subject>Pain - etiology</subject><subject>Pain Measurement</subject><subject>Peripheral Nerve Injuries - complications</subject><subject>Physical Stimulation - adverse effects</subject><subject>Psychophysics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Species Specificity</subject><issn>0304-3959</issn><issn>1872-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkFtLw0AQhRdRbK3-Bd0_kLq37OVRijco-KLPYdOdtKlpEnY3lP57N9aKOC_DGc75YA5Cd5TMKTHqfjvvbd3OyZ-hIhdnaEq1YpmUjJ-jKeFEZNzkZoKuQtgmE2PMXKIJJ1JTo9kUhUXXujrWXQsOj0y869zQ2PGCk_KdgzYGvLItrsDGwQPeHHrwtllDqC3u_Ki7k3TQQwK2a5zyEULEIda7oRlCokVoQx0P1-iisk2Am589Qx9Pj--Ll2z59vy6eFhmK55rkWlFuCBl-sUYSY3ISy5LKHMiS0ekIpXSThNDK-PyKudK6IoYo6xRwDg3lM-QOnJXvgvBQ1X0vt5ZfygoKcYai20xvlz8rzElb4_Jfih34H5zp96SQRwN-66J4MNnM-zBFxuwTdx88yQ3MmOEGiKSysaT4F8JnYBb</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Tansley, Shannon N.</creator><creator>Macintyre, Leigh C.</creator><creator>Diamond, Laura</creator><creator>Sotocinal, Susana G.</creator><creator>George, Nicole</creator><creator>Meluban, Lee</creator><creator>Austin, Jean-Sebastien</creator><creator>Coderre, Terence J.</creator><creator>Martin, Loren J.</creator><creator>Mogil, Jeffrey S.</creator><general>Wolters Kluwer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20190401</creationdate><title>Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity</title><author>Tansley, Shannon N. ; Macintyre, Leigh C. ; Diamond, Laura ; Sotocinal, Susana G. ; George, Nicole ; Meluban, Lee ; Austin, Jean-Sebastien ; Coderre, Terence J. ; Martin, Loren J. ; Mogil, Jeffrey S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3584-870340b6629961945b36beb506bd0670f78d8091f9d5f53748f0997a97e233913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acetic Acid - toxicity</topic><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Facial Pain - complications</topic><topic>Formaldehyde - toxicity</topic><topic>Hyperalgesia - etiology</topic><topic>Hypesthesia - etiology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred DBA</topic><topic>Pain - complications</topic><topic>Pain - etiology</topic><topic>Pain Measurement</topic><topic>Peripheral Nerve Injuries - complications</topic><topic>Physical Stimulation - adverse effects</topic><topic>Psychophysics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tansley, Shannon N.</creatorcontrib><creatorcontrib>Macintyre, Leigh C.</creatorcontrib><creatorcontrib>Diamond, Laura</creatorcontrib><creatorcontrib>Sotocinal, Susana G.</creatorcontrib><creatorcontrib>George, Nicole</creatorcontrib><creatorcontrib>Meluban, Lee</creatorcontrib><creatorcontrib>Austin, Jean-Sebastien</creatorcontrib><creatorcontrib>Coderre, Terence J.</creatorcontrib><creatorcontrib>Martin, Loren J.</creatorcontrib><creatorcontrib>Mogil, Jeffrey S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Pain (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tansley, Shannon N.</au><au>Macintyre, Leigh C.</au><au>Diamond, Laura</au><au>Sotocinal, Susana G.</au><au>George, Nicole</au><au>Meluban, Lee</au><au>Austin, Jean-Sebastien</au><au>Coderre, Terence J.</au><au>Martin, Loren J.</au><au>Mogil, Jeffrey S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity</atitle><jtitle>Pain (Amsterdam)</jtitle><addtitle>Pain</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>160</volume><issue>4</issue><spage>784</spage><epage>792</epage><pages>784-792</pages><issn>0304-3959</issn><eissn>1872-6623</eissn><abstract>The counterirritation phenomenon known as conditioned pain modulation, or diffuse noxious inhibitory control in animals, is of increasing interest due to its utility in predicting chronic pain and treatment response. It features considerable interindividual variability, with large subsets of pain patients and even normal volunteers exhibiting hyperalgesia rather than hypoalgesia during or immediately after receiving a conditioning stimulus. We observed that mice undergoing tonic inflammatory pain in the abdominal cavity (the conditioning stimulus) display hyperalgesia, not hypoalgesia, to noxious thermal stimulation (the test stimulus) applied to the hindpaw. In a series of parametric studies, we show that this hyperalgesia can be reliably observed using multiple conditioning stimuli (acetic acid and orofacial formalin), test stimuli (hindpaw and forepaw-withdrawal, tail-withdrawal, hot-plate, and von Frey tests) and genotypes (CD-1, DBA/2, and C57BL/6 mice and Sprague-Dawley rats). Although the magnitude of the hyperalgesia is dependent on the intensity of the conditioning stimulus, we find that the direction of effect is dependent on the effective test stimulus intensity, with lower-intensity stimuli leading to hyperalgesia and higher-intensity stimuli leading to hypoalgesia.</abstract><cop>United States</cop><pub>Wolters Kluwer</pub><pmid>30681982</pmid><doi>10.1097/j.pain.0000000000001454</doi><tpages>9</tpages></addata></record> |
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subjects | Acetic Acid - toxicity Animals Disease Models, Animal Dose-Response Relationship, Drug Facial Pain - complications Formaldehyde - toxicity Hyperalgesia - etiology Hypesthesia - etiology Male Mice Mice, Inbred C57BL Mice, Inbred DBA Pain - complications Pain - etiology Pain Measurement Peripheral Nerve Injuries - complications Physical Stimulation - adverse effects Psychophysics Rats Rats, Sprague-Dawley Species Specificity |
title | Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity |
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