Naringenin ameliorates kainic acid-induced morphological alterations in the dentate gyrus in a mouse model of temporal lobe epilepsy

Granule cell dispersion (GCD) in the dentate gyrus (DG) of the hippocampus is a morphological alteration characteristic of temporal lobe epilepsy. Recently, we reported that treatment with naringin, a flavonoid found in grapefruit and citrus fruits, reduced spontaneous recurrent seizures by inhibiti...

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Veröffentlicht in:	Neuroreport 2016-10, Vol.27 (15), p.1182-1189
Hauptverfasser:	Park, Jungha, Jeong, Kyoung Hoon, Shin, Won-Ho, Bae, Young-Seuk, Jung, Un Ju, Kim, Sang Ryong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - therapeutic use Carrier Proteins - metabolism Cytokines Dentate Gyrus - drug effects Disease Models, Animal Dose-Response Relationship, Drug Epilepsy, Temporal Lobe - chemically induced Epilepsy, Temporal Lobe - drug therapy Epilepsy, Temporal Lobe - pathology Excitatory Amino Acid Agonists - toxicity Flavanones - therapeutic use Kainic Acid - toxicity Male Mechanistic Target of Rapamycin Complex 1 - metabolism Mice Mice, Inbred C57BL Microglia - drug effects Nerve Tissue Proteins - metabolism Phosphoproteins - metabolism
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