Pyridoxal plasma level in schizophrenic and schizoaffective patients with and without tardive dyskinesia
Motor disturbances in vitamin B6-deficient animals were described. Some clinical experiments showed that vitamin B6 may ameliorate different drug-induced movement disorders, including tardive dyskinesia (TD). The aim of this study was to compare plasma pyridoxal-5-phosphate (PLP) levels in schizophr...
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| Veröffentlicht in: | Clinical neuropharmacology 2008-07, Vol.31 (4), p.197-203 |
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| creator | Miodownik, Chanoch Meoded, Aviel Libov, Igor Bersudsky, Yuly Sela, Ben-Ami Lerner, Vladimir |
| description | Motor disturbances in vitamin B6-deficient animals were described. Some clinical experiments showed that vitamin B6 may ameliorate different drug-induced movement disorders, including tardive dyskinesia (TD). The aim of this study was to compare plasma pyridoxal-5-phosphate (PLP) levels in schizophrenic patients with and without TD.
This study was conducted in the Be'er Sheva Mental Health Center from February 2006 to August 2006. Eighty-nine schizophrenic inpatients (40 have TD, 22 men and 18 women, 20-66 yrs old [mean, 48 yrs] and 49 schizophrenic inpatients, 30 men and 19 women, 21-66 yrs old (mean, 49 yrs), without any symptoms of motor disturbances [the control group]) were enrolled in the study. Measurement of PLP is performed by high-performance liquid chromatography separation in all patients.
There was a significant difference in plasma PLP levels between patients with TD and those without TD. The discrepancy between the groups was almost entirely attributable to the PLP levels of male patients: 12.4 +/- 11.4 vs 29.0 +/- 12.9 nM in men (P < 0.001), and 19.7 +/- 14.8 vs 22.0 +/- 13.6 nM in women (P > 0.5).
Our results suggest that schizophrenic and schizoaffective male patients with TD have lower PLP plasma levels than non-TD patients. |
| doi_str_mv | 10.1097/WNF.0b013e3181506623 |
| format | Article |
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This study was conducted in the Be'er Sheva Mental Health Center from February 2006 to August 2006. Eighty-nine schizophrenic inpatients (40 have TD, 22 men and 18 women, 20-66 yrs old [mean, 48 yrs] and 49 schizophrenic inpatients, 30 men and 19 women, 21-66 yrs old (mean, 49 yrs), without any symptoms of motor disturbances [the control group]) were enrolled in the study. Measurement of PLP is performed by high-performance liquid chromatography separation in all patients.
There was a significant difference in plasma PLP levels between patients with TD and those without TD. The discrepancy between the groups was almost entirely attributable to the PLP levels of male patients: 12.4 +/- 11.4 vs 29.0 +/- 12.9 nM in men (P < 0.001), and 19.7 +/- 14.8 vs 22.0 +/- 13.6 nM in women (P > 0.5).
Our results suggest that schizophrenic and schizoaffective male patients with TD have lower PLP plasma levels than non-TD patients.</description><identifier>ISSN: 0362-5664</identifier><identifier>EISSN: 1537-162X</identifier><identifier>DOI: 10.1097/WNF.0b013e3181506623</identifier><identifier>PMID: 18670243</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Dyskinesia, Drug-Induced - blood ; Dyskinesia, Drug-Induced - etiology ; Female ; Humans ; Male ; Middle Aged ; Psychotic Disorders - blood ; Psychotic Disorders - complications ; Pyridoxal Phosphate - blood ; Schizophrenia - blood ; Schizophrenia - complications</subject><ispartof>Clinical neuropharmacology, 2008-07, Vol.31 (4), p.197-203</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-5618d2ba9b45a9134a6bdf19628f811e172906a77ffea27d00a351b7cb6ce513</citedby><cites>FETCH-LOGICAL-c305t-5618d2ba9b45a9134a6bdf19628f811e172906a77ffea27d00a351b7cb6ce513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18670243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miodownik, Chanoch</creatorcontrib><creatorcontrib>Meoded, Aviel</creatorcontrib><creatorcontrib>Libov, Igor</creatorcontrib><creatorcontrib>Bersudsky, Yuly</creatorcontrib><creatorcontrib>Sela, Ben-Ami</creatorcontrib><creatorcontrib>Lerner, Vladimir</creatorcontrib><title>Pyridoxal plasma level in schizophrenic and schizoaffective patients with and without tardive dyskinesia</title><title>Clinical neuropharmacology</title><addtitle>Clin Neuropharmacol</addtitle><description>Motor disturbances in vitamin B6-deficient animals were described. Some clinical experiments showed that vitamin B6 may ameliorate different drug-induced movement disorders, including tardive dyskinesia (TD). The aim of this study was to compare plasma pyridoxal-5-phosphate (PLP) levels in schizophrenic patients with and without TD.
This study was conducted in the Be'er Sheva Mental Health Center from February 2006 to August 2006. Eighty-nine schizophrenic inpatients (40 have TD, 22 men and 18 women, 20-66 yrs old [mean, 48 yrs] and 49 schizophrenic inpatients, 30 men and 19 women, 21-66 yrs old (mean, 49 yrs), without any symptoms of motor disturbances [the control group]) were enrolled in the study. Measurement of PLP is performed by high-performance liquid chromatography separation in all patients.
There was a significant difference in plasma PLP levels between patients with TD and those without TD. The discrepancy between the groups was almost entirely attributable to the PLP levels of male patients: 12.4 +/- 11.4 vs 29.0 +/- 12.9 nM in men (P < 0.001), and 19.7 +/- 14.8 vs 22.0 +/- 13.6 nM in women (P > 0.5).
Our results suggest that schizophrenic and schizoaffective male patients with TD have lower PLP plasma levels than non-TD patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Dyskinesia, Drug-Induced - blood</subject><subject>Dyskinesia, Drug-Induced - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Psychotic Disorders - blood</subject><subject>Psychotic Disorders - complications</subject><subject>Pyridoxal Phosphate - blood</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenia - complications</subject><issn>0362-5664</issn><issn>1537-162X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkNFKw0AQRRdRbK3-gcj-QOrMbrKbPEqxVSjqQ0HfwiS7IatpErJptX69qS0IPs0w3DNcDmPXCFOERN--Ps2nkAFKKzHGCJQS8oSNMZI6QCXeTtkYpBJBpFQ4YhfevwNAnITJORthrDSIUI5Z-bLrnGm-qOJtRX5NvLJbW3FXc5-X7rtpy87WLudUm-OFisLmvdta3lLvbN17_un68jexX5pNz3vqzD5hdv7D1dY7umRnBVXeXh3nhK3m96vZQ7B8XjzO7pZBLiHqh7YYG5FRkoURJShDUpkpMFEiLmJEi1okoEjroQQJbQBIRpjpPFO5jVBOWHh4m3eN950t0rZza-p2KUK695YO3tL_3gbs5oC1m2xtzR90FCV_AFJabD4</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Miodownik, Chanoch</creator><creator>Meoded, Aviel</creator><creator>Libov, Igor</creator><creator>Bersudsky, Yuly</creator><creator>Sela, Ben-Ami</creator><creator>Lerner, Vladimir</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200807</creationdate><title>Pyridoxal plasma level in schizophrenic and schizoaffective patients with and without tardive dyskinesia</title><author>Miodownik, Chanoch ; Meoded, Aviel ; Libov, Igor ; Bersudsky, Yuly ; Sela, Ben-Ami ; Lerner, Vladimir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-5618d2ba9b45a9134a6bdf19628f811e172906a77ffea27d00a351b7cb6ce513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Dyskinesia, Drug-Induced - blood</topic><topic>Dyskinesia, Drug-Induced - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Psychotic Disorders - blood</topic><topic>Psychotic Disorders - complications</topic><topic>Pyridoxal Phosphate - blood</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenia - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miodownik, Chanoch</creatorcontrib><creatorcontrib>Meoded, Aviel</creatorcontrib><creatorcontrib>Libov, Igor</creatorcontrib><creatorcontrib>Bersudsky, Yuly</creatorcontrib><creatorcontrib>Sela, Ben-Ami</creatorcontrib><creatorcontrib>Lerner, Vladimir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Clinical neuropharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miodownik, Chanoch</au><au>Meoded, Aviel</au><au>Libov, Igor</au><au>Bersudsky, Yuly</au><au>Sela, Ben-Ami</au><au>Lerner, Vladimir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pyridoxal plasma level in schizophrenic and schizoaffective patients with and without tardive dyskinesia</atitle><jtitle>Clinical neuropharmacology</jtitle><addtitle>Clin Neuropharmacol</addtitle><date>2008-07</date><risdate>2008</risdate><volume>31</volume><issue>4</issue><spage>197</spage><epage>203</epage><pages>197-203</pages><issn>0362-5664</issn><eissn>1537-162X</eissn><abstract>Motor disturbances in vitamin B6-deficient animals were described. Some clinical experiments showed that vitamin B6 may ameliorate different drug-induced movement disorders, including tardive dyskinesia (TD). The aim of this study was to compare plasma pyridoxal-5-phosphate (PLP) levels in schizophrenic patients with and without TD.
This study was conducted in the Be'er Sheva Mental Health Center from February 2006 to August 2006. Eighty-nine schizophrenic inpatients (40 have TD, 22 men and 18 women, 20-66 yrs old [mean, 48 yrs] and 49 schizophrenic inpatients, 30 men and 19 women, 21-66 yrs old (mean, 49 yrs), without any symptoms of motor disturbances [the control group]) were enrolled in the study. Measurement of PLP is performed by high-performance liquid chromatography separation in all patients.
There was a significant difference in plasma PLP levels between patients with TD and those without TD. The discrepancy between the groups was almost entirely attributable to the PLP levels of male patients: 12.4 +/- 11.4 vs 29.0 +/- 12.9 nM in men (P < 0.001), and 19.7 +/- 14.8 vs 22.0 +/- 13.6 nM in women (P > 0.5).
Our results suggest that schizophrenic and schizoaffective male patients with TD have lower PLP plasma levels than non-TD patients.</abstract><cop>United States</cop><pmid>18670243</pmid><doi>10.1097/WNF.0b013e3181506623</doi><tpages>7</tpages></addata></record> |
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| ispartof | Clinical neuropharmacology, 2008-07, Vol.31 (4), p.197-203 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Dyskinesia, Drug-Induced - blood Dyskinesia, Drug-Induced - etiology Female Humans Male Middle Aged Psychotic Disorders - blood Psychotic Disorders - complications Pyridoxal Phosphate - blood Schizophrenia - blood Schizophrenia - complications |
| title | Pyridoxal plasma level in schizophrenic and schizoaffective patients with and without tardive dyskinesia |
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