Early Diagnosis of Intestinal Ischemia Using Urinary and Plasma Fatty Acid Binding Proteins
This study aims at improving diagnosis of intestinal ischemia, by measuring plasma and urinary fatty acid binding protein (FABP) levels. Fifty consecutive patients suspected of intestinal ischemia were included and blood and urine were sampled at time of suspicion. Plasma and urinary concentrations...
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| Veröffentlicht in: | Annals of surgery 2011-02, Vol.253 (2), p.303-308 |
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| creator | THUIJLS, Geertje VAN WIJCK, Kim GROOTJANS, Joep DERIKX, Joep P. M VAN BIJNEN, Annemarie A HEINEMAN, Erik DEJONG, Cornelis H. C BUURMAN, Wim A POEZE, Martijn |
| description | This study aims at improving diagnosis of intestinal ischemia, by measuring plasma and urinary fatty acid binding protein (FABP) levels.
Fifty consecutive patients suspected of intestinal ischemia were included and blood and urine were sampled at time of suspicion. Plasma and urinary concentrations of intestinal FABP (I-FABP), liver FABP (L-FABP) and ileal bile acid binding protein (I-BABP) were measured using enzyme-linked immunosorbent assays.
Twenty-two patients suspected of intestinal ischemia were diagnosed with intestinal ischemia, 24 patients were diagnosed with other diseases, and 4 patients were excluded from further analysis fulfilling exclusion criteria. Median plasma concentrations of I-FABP and L-FABP and urinary concentrations of all 3 markers were significantly higher in patients with proven intestinal ischemia than in patients suspected of intestinal ischemia with other final diagnoses (plasma I-FABP; 653 pg/mL vs. 109 pg/mL, P = 0.02, plasma L-FABP; 117 ng/mL vs. 25 ng/mL, P = 0.006, urine I-FABP; 3377 pg/mL vs. 115 pg/mL, P = 0.001, urine L-FABP; 1,199 ng/mL vs. 37 ng/mL, P =0.004, urine I-BABP; 48.6 ng/mL vs. 0.6 ng/mL, P = 0.002). Positive and negative likelihood ratios significantly increased positive posttest probability and decreased negative posttest probability on intestinal ischemia. In patients with intestinal ischemia a trend to higher plasma I-BABP levels was observed when the ileum was involved (18.4 ng/mL vs. 2.9 ng/mL, P = 0.05).
Plasma and especially urinary I-FABP and L-FABP levels and urinary I-BABP levels can improve early diagnosis of intestinal ischemia. Furthermore, plasma I-BABP levels can help in localizing ileal ischemia. |
| doi_str_mv | 10.1097/sla.0b013e318207a767 |
| format | Article |
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Fifty consecutive patients suspected of intestinal ischemia were included and blood and urine were sampled at time of suspicion. Plasma and urinary concentrations of intestinal FABP (I-FABP), liver FABP (L-FABP) and ileal bile acid binding protein (I-BABP) were measured using enzyme-linked immunosorbent assays.
Twenty-two patients suspected of intestinal ischemia were diagnosed with intestinal ischemia, 24 patients were diagnosed with other diseases, and 4 patients were excluded from further analysis fulfilling exclusion criteria. Median plasma concentrations of I-FABP and L-FABP and urinary concentrations of all 3 markers were significantly higher in patients with proven intestinal ischemia than in patients suspected of intestinal ischemia with other final diagnoses (plasma I-FABP; 653 pg/mL vs. 109 pg/mL, P = 0.02, plasma L-FABP; 117 ng/mL vs. 25 ng/mL, P = 0.006, urine I-FABP; 3377 pg/mL vs. 115 pg/mL, P = 0.001, urine L-FABP; 1,199 ng/mL vs. 37 ng/mL, P =0.004, urine I-BABP; 48.6 ng/mL vs. 0.6 ng/mL, P = 0.002). Positive and negative likelihood ratios significantly increased positive posttest probability and decreased negative posttest probability on intestinal ischemia. In patients with intestinal ischemia a trend to higher plasma I-BABP levels was observed when the ileum was involved (18.4 ng/mL vs. 2.9 ng/mL, P = 0.05).
Plasma and especially urinary I-FABP and L-FABP levels and urinary I-BABP levels can improve early diagnosis of intestinal ischemia. Furthermore, plasma I-BABP levels can help in localizing ileal ischemia.</description><identifier>ISSN: 0003-4932</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/sla.0b013e318207a767</identifier><identifier>PMID: 21245670</identifier><identifier>CODEN: ANSUA5</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Acute Disease ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers - blood ; Biomarkers - urine ; Child ; Early Diagnosis ; Fatty Acid-Binding Proteins - blood ; Fatty Acid-Binding Proteins - urine ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal Hormones - urine ; General aspects ; Humans ; Intestines - blood supply ; Ischemia - diagnosis ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Sensitivity and Specificity ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Young Adult</subject><ispartof>Annals of surgery, 2011-02, Vol.253 (2), p.303-308</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-5fe8dc77a3a1c5fbf61e434fc4e99e8762471ef40334e247cb4a4708a74fdc2a3</citedby><cites>FETCH-LOGICAL-c402t-5fe8dc77a3a1c5fbf61e434fc4e99e8762471ef40334e247cb4a4708a74fdc2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23784034$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21245670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>THUIJLS, Geertje</creatorcontrib><creatorcontrib>VAN WIJCK, Kim</creatorcontrib><creatorcontrib>GROOTJANS, Joep</creatorcontrib><creatorcontrib>DERIKX, Joep P. M</creatorcontrib><creatorcontrib>VAN BIJNEN, Annemarie A</creatorcontrib><creatorcontrib>HEINEMAN, Erik</creatorcontrib><creatorcontrib>DEJONG, Cornelis H. C</creatorcontrib><creatorcontrib>BUURMAN, Wim A</creatorcontrib><creatorcontrib>POEZE, Martijn</creatorcontrib><title>Early Diagnosis of Intestinal Ischemia Using Urinary and Plasma Fatty Acid Binding Proteins</title><title>Annals of surgery</title><addtitle>Ann Surg</addtitle><description>This study aims at improving diagnosis of intestinal ischemia, by measuring plasma and urinary fatty acid binding protein (FABP) levels.
Fifty consecutive patients suspected of intestinal ischemia were included and blood and urine were sampled at time of suspicion. Plasma and urinary concentrations of intestinal FABP (I-FABP), liver FABP (L-FABP) and ileal bile acid binding protein (I-BABP) were measured using enzyme-linked immunosorbent assays.
Twenty-two patients suspected of intestinal ischemia were diagnosed with intestinal ischemia, 24 patients were diagnosed with other diseases, and 4 patients were excluded from further analysis fulfilling exclusion criteria. Median plasma concentrations of I-FABP and L-FABP and urinary concentrations of all 3 markers were significantly higher in patients with proven intestinal ischemia than in patients suspected of intestinal ischemia with other final diagnoses (plasma I-FABP; 653 pg/mL vs. 109 pg/mL, P = 0.02, plasma L-FABP; 117 ng/mL vs. 25 ng/mL, P = 0.006, urine I-FABP; 3377 pg/mL vs. 115 pg/mL, P = 0.001, urine L-FABP; 1,199 ng/mL vs. 37 ng/mL, P =0.004, urine I-BABP; 48.6 ng/mL vs. 0.6 ng/mL, P = 0.002). Positive and negative likelihood ratios significantly increased positive posttest probability and decreased negative posttest probability on intestinal ischemia. In patients with intestinal ischemia a trend to higher plasma I-BABP levels was observed when the ileum was involved (18.4 ng/mL vs. 2.9 ng/mL, P = 0.05).
Plasma and especially urinary I-FABP and L-FABP levels and urinary I-BABP levels can improve early diagnosis of intestinal ischemia. Furthermore, plasma I-BABP levels can help in localizing ileal ischemia.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Child</subject><subject>Early Diagnosis</subject><subject>Fatty Acid-Binding Proteins - blood</subject><subject>Fatty Acid-Binding Proteins - urine</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal Hormones - urine</subject><subject>General aspects</subject><subject>Humans</subject><subject>Intestines - blood supply</subject><subject>Ischemia - diagnosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Sensitivity and Specificity</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Abdomen</topic><topic>Gastrointestinal Hormones - urine</topic><topic>General aspects</topic><topic>Humans</topic><topic>Intestines - blood supply</topic><topic>Ischemia - diagnosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Sensitivity and Specificity</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THUIJLS, Geertje</creatorcontrib><creatorcontrib>VAN WIJCK, Kim</creatorcontrib><creatorcontrib>GROOTJANS, Joep</creatorcontrib><creatorcontrib>DERIKX, Joep P. M</creatorcontrib><creatorcontrib>VAN BIJNEN, Annemarie A</creatorcontrib><creatorcontrib>HEINEMAN, Erik</creatorcontrib><creatorcontrib>DEJONG, Cornelis H. C</creatorcontrib><creatorcontrib>BUURMAN, Wim A</creatorcontrib><creatorcontrib>POEZE, Martijn</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Annals of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THUIJLS, Geertje</au><au>VAN WIJCK, Kim</au><au>GROOTJANS, Joep</au><au>DERIKX, Joep P. M</au><au>VAN BIJNEN, Annemarie A</au><au>HEINEMAN, Erik</au><au>DEJONG, Cornelis H. C</au><au>BUURMAN, Wim A</au><au>POEZE, Martijn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Diagnosis of Intestinal Ischemia Using Urinary and Plasma Fatty Acid Binding Proteins</atitle><jtitle>Annals of surgery</jtitle><addtitle>Ann Surg</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>253</volume><issue>2</issue><spage>303</spage><epage>308</epage><pages>303-308</pages><issn>0003-4932</issn><eissn>1528-1140</eissn><coden>ANSUA5</coden><abstract>This study aims at improving diagnosis of intestinal ischemia, by measuring plasma and urinary fatty acid binding protein (FABP) levels.
Fifty consecutive patients suspected of intestinal ischemia were included and blood and urine were sampled at time of suspicion. Plasma and urinary concentrations of intestinal FABP (I-FABP), liver FABP (L-FABP) and ileal bile acid binding protein (I-BABP) were measured using enzyme-linked immunosorbent assays.
Twenty-two patients suspected of intestinal ischemia were diagnosed with intestinal ischemia, 24 patients were diagnosed with other diseases, and 4 patients were excluded from further analysis fulfilling exclusion criteria. Median plasma concentrations of I-FABP and L-FABP and urinary concentrations of all 3 markers were significantly higher in patients with proven intestinal ischemia than in patients suspected of intestinal ischemia with other final diagnoses (plasma I-FABP; 653 pg/mL vs. 109 pg/mL, P = 0.02, plasma L-FABP; 117 ng/mL vs. 25 ng/mL, P = 0.006, urine I-FABP; 3377 pg/mL vs. 115 pg/mL, P = 0.001, urine L-FABP; 1,199 ng/mL vs. 37 ng/mL, P =0.004, urine I-BABP; 48.6 ng/mL vs. 0.6 ng/mL, P = 0.002). Positive and negative likelihood ratios significantly increased positive posttest probability and decreased negative posttest probability on intestinal ischemia. In patients with intestinal ischemia a trend to higher plasma I-BABP levels was observed when the ileum was involved (18.4 ng/mL vs. 2.9 ng/mL, P = 0.05).
Plasma and especially urinary I-FABP and L-FABP levels and urinary I-BABP levels can improve early diagnosis of intestinal ischemia. Furthermore, plasma I-BABP levels can help in localizing ileal ischemia.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>21245670</pmid><doi>10.1097/sla.0b013e318207a767</doi><tpages>6</tpages></addata></record> |
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| subjects | Acute Disease Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers - blood Biomarkers - urine Child Early Diagnosis Fatty Acid-Binding Proteins - blood Fatty Acid-Binding Proteins - urine Female Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Hormones - urine General aspects Humans Intestines - blood supply Ischemia - diagnosis Male Medical sciences Middle Aged Other diseases. Semiology Sensitivity and Specificity Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Young Adult |
| title | Early Diagnosis of Intestinal Ischemia Using Urinary and Plasma Fatty Acid Binding Proteins |
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