Importance of Local Ablative Therapies for Lung Metastases in Patients With Colorectal Cancer
To assess the effect of local ablative therapy (LAT) on overall survival in patients with lung metastases from colorectal cancer (CRC) compared with patients treated with systemic therapy. CRC affects approximately 1.4 million individuals worldwide every year. The lungs are commonly affected by CRC,...
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| Veröffentlicht in: | Annals of surgery 2023-07, Vol.278 (1), p.e173-e178 |
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| creator | Lee, Byung Min Chang, Jee Suk Koom, Woong Sub Byun, Hwa Kyung Kim, Han Sang Beom, Seung-Hoon Oh, Caleb Suh, Young Joo Ahn, Joong Bae Shin, Sang Joon Park, Byung Jo Park, Seong Yong |
| description | To assess the effect of local ablative therapy (LAT) on overall survival in patients with lung metastases from colorectal cancer (CRC) compared with patients treated with systemic therapy.
CRC affects approximately 1.4 million individuals worldwide every year. The lungs are commonly affected by CRC, and there is no treatment standard for a secondary lung metastasis from CRC.
This longitudinal, retrospective cohort study (2010-2018) quantified the pulmonary and extrapulmonary tumor burden of 1143 patients by retrospectively reviewing computed tomography images captured at diagnosis. A comprehensive multidisciplinary approach informed how and when surgery and/or stereotactic body radiotherapy was administered.
Among 1143 patients, 473 patients (41%) received LAT, with surgery first (n = 421) or stereotactic ablative radiation therapy first (n = 52) either at the time of diagnosis (n = 288), within 1 year (n = 132), or after 1 year (n = 53). LAT was repeated in 158 patients (33.4%, 384 total sessions) when new lung metastases were detected. The 5- and 10-year survival rates for patients treated with LAT (71.2% and 64.0%, respectively) were significantly higher than those of patients treated with systemic therapy alone (14.2% and 10.0%, respectively; P |
| doi_str_mv | 10.1097/SLA.0000000000005466 |
| format | Article |
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CRC affects approximately 1.4 million individuals worldwide every year. The lungs are commonly affected by CRC, and there is no treatment standard for a secondary lung metastasis from CRC.
This longitudinal, retrospective cohort study (2010-2018) quantified the pulmonary and extrapulmonary tumor burden of 1143 patients by retrospectively reviewing computed tomography images captured at diagnosis. A comprehensive multidisciplinary approach informed how and when surgery and/or stereotactic body radiotherapy was administered.
Among 1143 patients, 473 patients (41%) received LAT, with surgery first (n = 421) or stereotactic ablative radiation therapy first (n = 52) either at the time of diagnosis (n = 288), within 1 year (n = 132), or after 1 year (n = 53). LAT was repeated in 158 patients (33.4%, 384 total sessions) when new lung metastases were detected. The 5- and 10-year survival rates for patients treated with LAT (71.2% and 64.0%, respectively) were significantly higher than those of patients treated with systemic therapy alone (14.2% and 10.0%, respectively; P <0.001). The overall survival of patients who received LAT intervention increased as the total tumor burden decreased.
A high long-term survival rate was achievable in a significant portion of patients with lung metastasis from CRC by the timely administrations of LAT to standard systemic therapy. The tumor burden and LAT feasibility should be included in a discussion during the follow-up period.</description><identifier>ISSN: 0003-4932</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/SLA.0000000000005466</identifier><identifier>PMID: 35837890</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><ispartof>Annals of surgery, 2023-07, Vol.278 (1), p.e173-e178</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3195-1aa2613f793927d6bca90b69931429533ee9abf95b5902afec05bb6657d9696c3</citedby><cites>FETCH-LOGICAL-c3195-1aa2613f793927d6bca90b69931429533ee9abf95b5902afec05bb6657d9696c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35837890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Byung Min</creatorcontrib><creatorcontrib>Chang, Jee Suk</creatorcontrib><creatorcontrib>Koom, Woong Sub</creatorcontrib><creatorcontrib>Byun, Hwa Kyung</creatorcontrib><creatorcontrib>Kim, Han Sang</creatorcontrib><creatorcontrib>Beom, Seung-Hoon</creatorcontrib><creatorcontrib>Oh, Caleb</creatorcontrib><creatorcontrib>Suh, Young Joo</creatorcontrib><creatorcontrib>Ahn, Joong Bae</creatorcontrib><creatorcontrib>Shin, Sang Joon</creatorcontrib><creatorcontrib>Park, Byung Jo</creatorcontrib><creatorcontrib>Park, Seong Yong</creatorcontrib><title>Importance of Local Ablative Therapies for Lung Metastases in Patients With Colorectal Cancer</title><title>Annals of surgery</title><addtitle>Ann Surg</addtitle><description>To assess the effect of local ablative therapy (LAT) on overall survival in patients with lung metastases from colorectal cancer (CRC) compared with patients treated with systemic therapy.
CRC affects approximately 1.4 million individuals worldwide every year. The lungs are commonly affected by CRC, and there is no treatment standard for a secondary lung metastasis from CRC.
This longitudinal, retrospective cohort study (2010-2018) quantified the pulmonary and extrapulmonary tumor burden of 1143 patients by retrospectively reviewing computed tomography images captured at diagnosis. A comprehensive multidisciplinary approach informed how and when surgery and/or stereotactic body radiotherapy was administered.
Among 1143 patients, 473 patients (41%) received LAT, with surgery first (n = 421) or stereotactic ablative radiation therapy first (n = 52) either at the time of diagnosis (n = 288), within 1 year (n = 132), or after 1 year (n = 53). LAT was repeated in 158 patients (33.4%, 384 total sessions) when new lung metastases were detected. The 5- and 10-year survival rates for patients treated with LAT (71.2% and 64.0%, respectively) were significantly higher than those of patients treated with systemic therapy alone (14.2% and 10.0%, respectively; P <0.001). The overall survival of patients who received LAT intervention increased as the total tumor burden decreased.
A high long-term survival rate was achievable in a significant portion of patients with lung metastasis from CRC by the timely administrations of LAT to standard systemic therapy. The tumor burden and LAT feasibility should be included in a discussion during the follow-up period.</description><issn>0003-4932</issn><issn>1528-1140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkNtKxDAQhoMo7np4A5G8QNccmrS5XIqHhYqCK15JSbNTW-02S5J18e3Nsp5wmGGYn_m_ix-hM0omlKjs4qGcTsifEqmUe2hMBcsTSlOyj8ZR5UmqOBuhI-9fCaFpTrJDNOIi51muyBg9z5Yr64IeDGDb4NIa3eNp3evQvQOet-D0qgOPG-twuR5e8C0E7WNHrRvwffyDIXj81IUWF7a3DkyIiGJLdCfooNG9h9OvfYwery7nxU1S3l3PimmZGE6VSKjWTFLeZIorli1kbbQitVSK05QpwTmA0nWjRC0UYboBQ0RdSymyhZJKGn6M0h3XOOu9g6ZauW6p3UdFSbVNq4ppVf_TirbznW21rpew-DF9x_PL3dg-gPNv_XoDrmpB96Hd8aTIE0YYJ1k8kjip4J_rUXR-</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Lee, Byung Min</creator><creator>Chang, Jee Suk</creator><creator>Koom, Woong Sub</creator><creator>Byun, Hwa Kyung</creator><creator>Kim, Han Sang</creator><creator>Beom, Seung-Hoon</creator><creator>Oh, Caleb</creator><creator>Suh, Young Joo</creator><creator>Ahn, Joong Bae</creator><creator>Shin, Sang Joon</creator><creator>Park, Byung Jo</creator><creator>Park, Seong Yong</creator><general>Lippincott Williams & Wilkins</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20230701</creationdate><title>Importance of Local Ablative Therapies for Lung Metastases in Patients With Colorectal Cancer</title><author>Lee, Byung Min ; Chang, Jee Suk ; Koom, Woong Sub ; Byun, Hwa Kyung ; Kim, Han Sang ; Beom, Seung-Hoon ; Oh, Caleb ; Suh, Young Joo ; Ahn, Joong Bae ; Shin, Sang Joon ; Park, Byung Jo ; Park, Seong Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3195-1aa2613f793927d6bca90b69931429533ee9abf95b5902afec05bb6657d9696c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Byung Min</creatorcontrib><creatorcontrib>Chang, Jee Suk</creatorcontrib><creatorcontrib>Koom, Woong Sub</creatorcontrib><creatorcontrib>Byun, Hwa Kyung</creatorcontrib><creatorcontrib>Kim, Han Sang</creatorcontrib><creatorcontrib>Beom, Seung-Hoon</creatorcontrib><creatorcontrib>Oh, Caleb</creatorcontrib><creatorcontrib>Suh, Young Joo</creatorcontrib><creatorcontrib>Ahn, Joong Bae</creatorcontrib><creatorcontrib>Shin, Sang Joon</creatorcontrib><creatorcontrib>Park, Byung Jo</creatorcontrib><creatorcontrib>Park, Seong Yong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Annals of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Byung Min</au><au>Chang, Jee Suk</au><au>Koom, Woong Sub</au><au>Byun, Hwa Kyung</au><au>Kim, Han Sang</au><au>Beom, Seung-Hoon</au><au>Oh, Caleb</au><au>Suh, Young Joo</au><au>Ahn, Joong Bae</au><au>Shin, Sang Joon</au><au>Park, Byung Jo</au><au>Park, Seong Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Importance of Local Ablative Therapies for Lung Metastases in Patients With Colorectal Cancer</atitle><jtitle>Annals of surgery</jtitle><addtitle>Ann Surg</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>278</volume><issue>1</issue><spage>e173</spage><epage>e178</epage><pages>e173-e178</pages><issn>0003-4932</issn><eissn>1528-1140</eissn><abstract>To assess the effect of local ablative therapy (LAT) on overall survival in patients with lung metastases from colorectal cancer (CRC) compared with patients treated with systemic therapy.
CRC affects approximately 1.4 million individuals worldwide every year. The lungs are commonly affected by CRC, and there is no treatment standard for a secondary lung metastasis from CRC.
This longitudinal, retrospective cohort study (2010-2018) quantified the pulmonary and extrapulmonary tumor burden of 1143 patients by retrospectively reviewing computed tomography images captured at diagnosis. A comprehensive multidisciplinary approach informed how and when surgery and/or stereotactic body radiotherapy was administered.
Among 1143 patients, 473 patients (41%) received LAT, with surgery first (n = 421) or stereotactic ablative radiation therapy first (n = 52) either at the time of diagnosis (n = 288), within 1 year (n = 132), or after 1 year (n = 53). LAT was repeated in 158 patients (33.4%, 384 total sessions) when new lung metastases were detected. The 5- and 10-year survival rates for patients treated with LAT (71.2% and 64.0%, respectively) were significantly higher than those of patients treated with systemic therapy alone (14.2% and 10.0%, respectively; P <0.001). The overall survival of patients who received LAT intervention increased as the total tumor burden decreased.
A high long-term survival rate was achievable in a significant portion of patients with lung metastasis from CRC by the timely administrations of LAT to standard systemic therapy. The tumor burden and LAT feasibility should be included in a discussion during the follow-up period.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>35837890</pmid><doi>10.1097/SLA.0000000000005466</doi></addata></record> |
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| title | Importance of Local Ablative Therapies for Lung Metastases in Patients With Colorectal Cancer |
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