Pharmacokinetic profiles of boosted darunavir, dolutegravir and lamivudine in aging people living with HIV

OBJECTIVES:The pharmacokinetics of antiretroviral drugs may differ in elderly people living with HIV (PLWH) because of age-related physiological changes. We aimed to assess the pharmacokinetics of several antiretroviral drugs in aging PLWH enrolled in the Swiss HIV Cohort (SHCS). DESIGN:Full pharmac...

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Veröffentlicht in:	AIDS (London) 2020-01, Vol.34 (1), p.103-108
Hauptverfasser:	Courlet, Perrine, Stader, Felix, Guidi, Monia, Alves Saldanha, Susana, Stoeckle, Marcel, Cavassini, Matthias, Battegay, Manuel, Buclin, Thierry, Decosterd, Laurent Arthur, Marzolini, Catia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging Anti-HIV Agents - pharmacokinetics Anti-HIV Agents - therapeutic use Darunavir - pharmacokinetics Darunavir - therapeutic use Drug Therapy, Combination Female Heterocyclic Compounds, 3-Ring - pharmacokinetics Heterocyclic Compounds, 3-Ring - therapeutic use HIV Infections - drug therapy HIV Infections - virology HIV Integrase Inhibitors - pharmacokinetics HIV Integrase Inhibitors - therapeutic use Humans Lamivudine - pharmacokinetics Lamivudine - therapeutic use Male Middle Aged Oxazines - pharmacokinetics Oxazines - therapeutic use Piperazines - pharmacokinetics Piperazines - therapeutic use Prospective Studies Pyridones - pharmacokinetics Pyridones - therapeutic use Viral Load
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