Role of Thrombospondin-1 and Nuclear Factor-κB Signaling Pathways in Antiangiogenesis of Infantile Hemangioma

Propranolol is the first-line drug for treatment of infantile hemangioma. However, its mechanism of action remains unclear. Nuclear factor-κB is highly expressed in tumors, directly or indirectly promoting angiogenesis. Thrombospondin-1 is the most important antiangiogenesis protein in vivo. These p...

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Veröffentlicht in:	Plastic and reconstructive surgery (1963) 2018-09, Vol.142 (3), p.310e-321e
Hauptverfasser:	Xu, Weili, Li, Suolin, Yu, Fengxue, Zhang, Yongting, Yang, Xiaofeng, An, Wenting, Wang, Wenbo, Sun, Chi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Adrenergic beta-Antagonists - therapeutic use Animals Cell Proliferation - drug effects Endothelial Cells - drug effects Female Hemangioma - drug therapy Hemangioma - pathology Humans I-kappa B Proteins - metabolism Infant Mice Mice, Inbred BALB C Mice, Nude Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology NF-KappaB Inhibitor alpha - metabolism Propranolol - pharmacology Propranolol - therapeutic use Signal Transduction - drug effects Skin Neoplasms - drug therapy Skin Neoplasms - pathology Thrombospondin 1 - metabolism Transcription Factor RelA - metabolism Treatment Outcome Tumor Cells, Cultured Xenograft Model Antitumor Assays
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