Effects of Botulinum Toxin on Improving Facial Surgical Scars: A Prospective, Split-Scar, Double-Blind, Randomized Controlled Trial
Early intervention might improve the quality of surgical scars. Botulinum toxin type A has been shown to improve surgical scars in the past decade. The purpose of this study was to evaluate the effect of botulinum toxin type A on surgical facial scars. In this prospective, split-scar, double-blind,...
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| Veröffentlicht in: | Plastic and reconstructive surgery (1963) 2018-03, Vol.141 (3), p.646-650 |
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| container_title | Plastic and reconstructive surgery (1963) |
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| creator | Hu, Li Zou, Yun Chang, Shih-Jen Qiu, Yajing Chen, Hui Gang, Ma Jin, Yunbo Lin, Xiaoxi |
| description | Early intervention might improve the quality of surgical scars. Botulinum toxin type A has been shown to improve surgical scars in the past decade. The purpose of this study was to evaluate the effect of botulinum toxin type A on surgical facial scars.
In this prospective, split-scar, double-blind, randomized controlled trial, 16 consecutive patients who underwent facial surgery between June and October of 2015 were enrolled. Botulinum toxin type A was injected randomly into half of each surgical wound closure immediately after surgery. The scars were assessed independently by two plastic surgeons at a 6-month follow-up visit using the Vancouver Scar Scale and the visual analogue scale. The scar width was also measured.
Fourteen patients completed the study. The visual analogue scale score and scar width measurements revealed a significant improvement in appearance and narrower scars for the botulinum toxin type A-treated halves of the scars (p = 0.046 and p = 0.001, respectively). The mean Vancouver Scar Scale score was 4.68 for the botulinum toxin type A-injected group and 5.24 for the control group (p = 0.15). In addition, the Vancouver Scar Scale height score was significantly different between the two groups (p = 0.008).
This study demonstrates that early postsurgical botulinum toxin injections can produce better, narrower, and flatter facial surgical scars.
Therapeutic, II. |
| doi_str_mv | 10.1097/PRS.0000000000004110 |
| format | Article |
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In this prospective, split-scar, double-blind, randomized controlled trial, 16 consecutive patients who underwent facial surgery between June and October of 2015 were enrolled. Botulinum toxin type A was injected randomly into half of each surgical wound closure immediately after surgery. The scars were assessed independently by two plastic surgeons at a 6-month follow-up visit using the Vancouver Scar Scale and the visual analogue scale. The scar width was also measured.
Fourteen patients completed the study. The visual analogue scale score and scar width measurements revealed a significant improvement in appearance and narrower scars for the botulinum toxin type A-treated halves of the scars (p = 0.046 and p = 0.001, respectively). The mean Vancouver Scar Scale score was 4.68 for the botulinum toxin type A-injected group and 5.24 for the control group (p = 0.15). In addition, the Vancouver Scar Scale height score was significantly different between the two groups (p = 0.008).
This study demonstrates that early postsurgical botulinum toxin injections can produce better, narrower, and flatter facial surgical scars.
Therapeutic, II.</description><identifier>ISSN: 0032-1052</identifier><identifier>EISSN: 1529-4242</identifier><identifier>DOI: 10.1097/PRS.0000000000004110</identifier><identifier>PMID: 29481395</identifier><language>eng</language><publisher>United States: by the American Society of Plastic Surgeons</publisher><subject>Adolescent ; Adult ; Botulinum Toxins, Type A - administration & dosage ; Child ; Cicatrix - drug therapy ; Dermatologic Agents - administration & dosage ; Double-Blind Method ; Facial Dermatoses - drug therapy ; Female ; Humans ; Injections, Intralesional ; Male ; Middle Aged ; Prospective Studies ; Treatment Outcome ; Young Adult</subject><ispartof>Plastic and reconstructive surgery (1963), 2018-03, Vol.141 (3), p.646-650</ispartof><rights>by the American Society of Plastic Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4184-b19b82107454711a3b0b6749ca7e89adb408890e663159ea5de37cae73f715ee3</citedby><cites>FETCH-LOGICAL-c4184-b19b82107454711a3b0b6749ca7e89adb408890e663159ea5de37cae73f715ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29481395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Li</creatorcontrib><creatorcontrib>Zou, Yun</creatorcontrib><creatorcontrib>Chang, Shih-Jen</creatorcontrib><creatorcontrib>Qiu, Yajing</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Gang, Ma</creatorcontrib><creatorcontrib>Jin, Yunbo</creatorcontrib><creatorcontrib>Lin, Xiaoxi</creatorcontrib><title>Effects of Botulinum Toxin on Improving Facial Surgical Scars: A Prospective, Split-Scar, Double-Blind, Randomized Controlled Trial</title><title>Plastic and reconstructive surgery (1963)</title><addtitle>Plast Reconstr Surg</addtitle><description>Early intervention might improve the quality of surgical scars. Botulinum toxin type A has been shown to improve surgical scars in the past decade. The purpose of this study was to evaluate the effect of botulinum toxin type A on surgical facial scars.
In this prospective, split-scar, double-blind, randomized controlled trial, 16 consecutive patients who underwent facial surgery between June and October of 2015 were enrolled. Botulinum toxin type A was injected randomly into half of each surgical wound closure immediately after surgery. The scars were assessed independently by two plastic surgeons at a 6-month follow-up visit using the Vancouver Scar Scale and the visual analogue scale. The scar width was also measured.
Fourteen patients completed the study. The visual analogue scale score and scar width measurements revealed a significant improvement in appearance and narrower scars for the botulinum toxin type A-treated halves of the scars (p = 0.046 and p = 0.001, respectively). The mean Vancouver Scar Scale score was 4.68 for the botulinum toxin type A-injected group and 5.24 for the control group (p = 0.15). In addition, the Vancouver Scar Scale height score was significantly different between the two groups (p = 0.008).
This study demonstrates that early postsurgical botulinum toxin injections can produce better, narrower, and flatter facial surgical scars.
Therapeutic, II.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Botulinum Toxins, Type A - administration & dosage</subject><subject>Child</subject><subject>Cicatrix - drug therapy</subject><subject>Dermatologic Agents - administration & dosage</subject><subject>Double-Blind Method</subject><subject>Facial Dermatoses - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Intralesional</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0032-1052</issn><issn>1529-4242</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkNFu1DAQRS1URLcLf4Aqf8C6eGI7jvvWLi2sVImquzxHTjJpDU4cOUkLvPbH8VKgiJFGc0ejezS6hLwFfgLc6HfXN9sT_k9JAP6CLEBlhslMZgdkwbnIGHCVHZKjcfzCOWiRq1fkMDOyAGHUgjxetC3W00hDS8_DNHvXzx3dhW-up6Gnm26I4d71t_TS1s56up3jrav3orZxPKVn9DqGcUgId48ruh28m9j-tqLvw1x5ZOcJ2azoje2b0Lkf2NB16KcYvE9yFxP0NXnZWj_im99zST5fXuzWH9nVpw-b9dkVqyUUklVgqiIDrqWSGsCKile5lqa2Ggtjm0ryojAc81yAMmhVg0LXFrVoNShEsSTyiVunl8eIbTlE19n4vQRe7jMtU6bl_5km2_GTbZirDpu_pj8hPnMfgp8wjl_9_ICxvEPrp7tfvFwJyTIOBRdpY6lBip_GX4Gt</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Hu, Li</creator><creator>Zou, Yun</creator><creator>Chang, Shih-Jen</creator><creator>Qiu, Yajing</creator><creator>Chen, Hui</creator><creator>Gang, Ma</creator><creator>Jin, Yunbo</creator><creator>Lin, Xiaoxi</creator><general>by the American Society of Plastic Surgeons</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20180301</creationdate><title>Effects of Botulinum Toxin on Improving Facial Surgical Scars: A Prospective, Split-Scar, Double-Blind, Randomized Controlled Trial</title><author>Hu, Li ; Zou, Yun ; Chang, Shih-Jen ; Qiu, Yajing ; Chen, Hui ; Gang, Ma ; Jin, Yunbo ; Lin, Xiaoxi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4184-b19b82107454711a3b0b6749ca7e89adb408890e663159ea5de37cae73f715ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Botulinum Toxins, Type A - administration & dosage</topic><topic>Child</topic><topic>Cicatrix - drug therapy</topic><topic>Dermatologic Agents - administration & dosage</topic><topic>Double-Blind Method</topic><topic>Facial Dermatoses - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Intralesional</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Li</creatorcontrib><creatorcontrib>Zou, Yun</creatorcontrib><creatorcontrib>Chang, Shih-Jen</creatorcontrib><creatorcontrib>Qiu, Yajing</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Gang, Ma</creatorcontrib><creatorcontrib>Jin, Yunbo</creatorcontrib><creatorcontrib>Lin, Xiaoxi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Plastic and reconstructive surgery (1963)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Li</au><au>Zou, Yun</au><au>Chang, Shih-Jen</au><au>Qiu, Yajing</au><au>Chen, Hui</au><au>Gang, Ma</au><au>Jin, Yunbo</au><au>Lin, Xiaoxi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Botulinum Toxin on Improving Facial Surgical Scars: A Prospective, Split-Scar, Double-Blind, Randomized Controlled Trial</atitle><jtitle>Plastic and reconstructive surgery (1963)</jtitle><addtitle>Plast Reconstr Surg</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>141</volume><issue>3</issue><spage>646</spage><epage>650</epage><pages>646-650</pages><issn>0032-1052</issn><eissn>1529-4242</eissn><abstract>Early intervention might improve the quality of surgical scars. Botulinum toxin type A has been shown to improve surgical scars in the past decade. The purpose of this study was to evaluate the effect of botulinum toxin type A on surgical facial scars.
In this prospective, split-scar, double-blind, randomized controlled trial, 16 consecutive patients who underwent facial surgery between June and October of 2015 were enrolled. Botulinum toxin type A was injected randomly into half of each surgical wound closure immediately after surgery. The scars were assessed independently by two plastic surgeons at a 6-month follow-up visit using the Vancouver Scar Scale and the visual analogue scale. The scar width was also measured.
Fourteen patients completed the study. The visual analogue scale score and scar width measurements revealed a significant improvement in appearance and narrower scars for the botulinum toxin type A-treated halves of the scars (p = 0.046 and p = 0.001, respectively). The mean Vancouver Scar Scale score was 4.68 for the botulinum toxin type A-injected group and 5.24 for the control group (p = 0.15). In addition, the Vancouver Scar Scale height score was significantly different between the two groups (p = 0.008).
This study demonstrates that early postsurgical botulinum toxin injections can produce better, narrower, and flatter facial surgical scars.
Therapeutic, II.</abstract><cop>United States</cop><pub>by the American Society of Plastic Surgeons</pub><pmid>29481395</pmid><doi>10.1097/PRS.0000000000004110</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Botulinum Toxins, Type A - administration & dosage Child Cicatrix - drug therapy Dermatologic Agents - administration & dosage Double-Blind Method Facial Dermatoses - drug therapy Female Humans Injections, Intralesional Male Middle Aged Prospective Studies Treatment Outcome Young Adult |
| title | Effects of Botulinum Toxin on Improving Facial Surgical Scars: A Prospective, Split-Scar, Double-Blind, Randomized Controlled Trial |
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