Effects of ubiquinone (coenzyme Q10) on myopathy in statin users

Statins are associated with muscle complaints, including myositis. The mechanism through which statin use causes muscle toxicity is unknown. One of the theories is that statin therapy reduces coenzyme Q10 levels in muscle mitochondria, which leads to muscle injury and myopathy. The aim of the presen...

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Veröffentlicht in:	Current opinion in lipidology 2008-12, Vol.19 (6), p.553-557
Hauptverfasser:	Schaars, Carel F, Stalenhoef, Anton FH
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Mitochondria - drug effects Mitochondria - enzymology Muscular Diseases - drug therapy Muscular Diseases - enzymology Ubiquinone - analogs & derivatives Ubiquinone - metabolism
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