Activation of Signal Transducers and Activators of Transcription 3 and Overexpression of its Target Gene CyclinD1 in Laryngeal Carcinomas

Objectives/Hypothesis: Constitutive activation of signal transducers and activators of transcription (STAT) 3 has been observed in many solid tumors including head and neck squamous cell carcinoma. Expression and activation of STAT3 in laryngeal carcinoma have not been fully understood. The study ai...

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Veröffentlicht in:	The Laryngoscope 2008-11, Vol.118 (11), p.1976-1980
Hauptverfasser:	Liu, Bin, Ren, Zhong, Shi, Yang, Guan, Chao, Pan, Zimin, Zong, Zhihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western carcinoma Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cyclin D1 - biosynthesis Cyclin D1 - genetics CyclinD1 Disease Progression Female Gene Expression Regulation, Neoplastic Gene Targeting Humans Laryngeal neoplasms Laryngeal Neoplasms - genetics Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - pathology Male Middle Aged Reverse Transcriptase Polymerase Chain Reaction RNA, Neoplasm - genetics squamous cell STAT3 STAT3 Transcription Factor - biosynthesis STAT3 Transcription Factor - genetics Transcriptional Activation
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