Gentamicin Increases Nitric Oxide Production and Induces Hearing Loss in Guinea Pigs

Objectives/Hypothesis: Gentamicin application is an important therapeutic option for Ménière's disease. However, even if given at intervals, a destruction of the cochlea was often observed in various animal models together with an increased content of nitric oxide (NO) and reactive oxygen speci...

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Veröffentlicht in:	The Laryngoscope 2008-08, Vol.118 (8), p.1438-1442
Hauptverfasser:	Heinrich, Ulf-Rüdiger, Helling, Kai, Sifferath, Marco, Brieger, Jürgen, Li, Huige, Schmidtmann, Irene, Mann, Wolf J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cochlea - metabolism Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Evoked Potentials, Auditory, Brain Stem gentamicin Gentamicins - toxicity Guinea Pigs Hearing Loss - chemically induced Hearing Loss - metabolism hearing threshold inner ear Male Medical sciences Nitric oxide Nitric Oxide - biosynthesis Non tumoral diseases Organ of Corti - metabolism Otorhinolaryngology. Stomatology Prospective Studies
Online-Zugang:	Volltext
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