Long-chain omega-3 fatty acids and cancer: any cause for concern?
PURPOSE OF REVIEWRecently, concerns have been raised with regard to the recommended doses of marine long-chain omega-3 polyunsaturated fatty acids (LC-omega-3 PUFAs) especially in relation to cancer risk and treatment. There is urgent need to clarify this point. This review considers the most recent...
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| Veröffentlicht in: | Current opinion in clinical nutrition and metabolic care 2018-03, Vol.21 (2), p.83-89 |
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| creator | Serini, Simona Calviello, Gabriella |
| description | PURPOSE OF REVIEWRecently, concerns have been raised with regard to the recommended doses of marine long-chain omega-3 polyunsaturated fatty acids (LC-omega-3 PUFAs) especially in relation to cancer risk and treatment. There is urgent need to clarify this point. This review considers the most recent evidence related to the potential risk of developing cancer with high LC-omega-3 PUFA intakes, and possible research strategies to better elucidate this matter.
RECENT FINDINGSThe latest published recommendations have still highlighted the usefulness of an increased dietary intake of LC-omega-3 PUFAs for the prevention of some cardiovascular diseases. However, LC-omega-3 PUFAs have been related to the potential development and progression of cancer, and considerable debate exists on this issue.
SUMMARYThe use of biomarkers reflecting the intake of LC-omega-3 PUFAs as cancer risk markers is discussed, as well as the possibility that the reported beneficial/deleterious effects may be confined to specific subpopulations on the basis of genetic, metabolic, and nutritional characteristics. Recent advances on new strategies for a safer intake of LC-omega-3 PUFAs will be considered, as their dietary sources may be contaminated by toxic/carcinogenic compounds. Potentially future directions in this important research area are also discussed. |
| doi_str_mv | 10.1097/MCO.0000000000000439 |
| format | Article |
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RECENT FINDINGSThe latest published recommendations have still highlighted the usefulness of an increased dietary intake of LC-omega-3 PUFAs for the prevention of some cardiovascular diseases. However, LC-omega-3 PUFAs have been related to the potential development and progression of cancer, and considerable debate exists on this issue.
SUMMARYThe use of biomarkers reflecting the intake of LC-omega-3 PUFAs as cancer risk markers is discussed, as well as the possibility that the reported beneficial/deleterious effects may be confined to specific subpopulations on the basis of genetic, metabolic, and nutritional characteristics. Recent advances on new strategies for a safer intake of LC-omega-3 PUFAs will be considered, as their dietary sources may be contaminated by toxic/carcinogenic compounds. Potentially future directions in this important research area are also discussed.</description><identifier>ISSN: 1363-1950</identifier><identifier>EISSN: 1473-6519</identifier><identifier>DOI: 10.1097/MCO.0000000000000439</identifier><identifier>PMID: 29232261</identifier><language>eng</language><publisher>England: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>alpha-Linolenic Acid - administration & dosage ; alpha-Linolenic Acid - adverse effects ; alpha-Linolenic Acid - blood ; Biomarkers, Tumor - blood ; Diet ; Dietary Supplements ; Docosahexaenoic Acids - administration & dosage ; Docosahexaenoic Acids - adverse effects ; Docosahexaenoic Acids - blood ; Eicosapentaenoic Acid - administration & dosage ; Eicosapentaenoic Acid - adverse effects ; Eicosapentaenoic Acid - blood ; Fatty Acids, Omega-3 - administration & dosage ; Fatty Acids, Omega-3 - adverse effects ; Fatty Acids, Omega-3 - blood ; Humans ; Neoplasms - blood ; Neoplasms - etiology ; Risk Factors</subject><ispartof>Current opinion in clinical nutrition and metabolic care, 2018-03, Vol.21 (2), p.83-89</ispartof><rights>Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3569-742eb750c7ebeff6c44bb25728e8e1a49be931bb74becd2b1448fe1816d5dfbd3</citedby><cites>FETCH-LOGICAL-c3569-742eb750c7ebeff6c44bb25728e8e1a49be931bb74becd2b1448fe1816d5dfbd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29232261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serini, Simona</creatorcontrib><creatorcontrib>Calviello, Gabriella</creatorcontrib><title>Long-chain omega-3 fatty acids and cancer: any cause for concern?</title><title>Current opinion in clinical nutrition and metabolic care</title><addtitle>Curr Opin Clin Nutr Metab Care</addtitle><description>PURPOSE OF REVIEWRecently, concerns have been raised with regard to the recommended doses of marine long-chain omega-3 polyunsaturated fatty acids (LC-omega-3 PUFAs) especially in relation to cancer risk and treatment. There is urgent need to clarify this point. This review considers the most recent evidence related to the potential risk of developing cancer with high LC-omega-3 PUFA intakes, and possible research strategies to better elucidate this matter.
RECENT FINDINGSThe latest published recommendations have still highlighted the usefulness of an increased dietary intake of LC-omega-3 PUFAs for the prevention of some cardiovascular diseases. However, LC-omega-3 PUFAs have been related to the potential development and progression of cancer, and considerable debate exists on this issue.
SUMMARYThe use of biomarkers reflecting the intake of LC-omega-3 PUFAs as cancer risk markers is discussed, as well as the possibility that the reported beneficial/deleterious effects may be confined to specific subpopulations on the basis of genetic, metabolic, and nutritional characteristics. Recent advances on new strategies for a safer intake of LC-omega-3 PUFAs will be considered, as their dietary sources may be contaminated by toxic/carcinogenic compounds. 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All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201803</creationdate><title>Long-chain omega-3 fatty acids and cancer: any cause for concern?</title><author>Serini, Simona ; Calviello, Gabriella</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3569-742eb750c7ebeff6c44bb25728e8e1a49be931bb74becd2b1448fe1816d5dfbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>alpha-Linolenic Acid - administration & dosage</topic><topic>alpha-Linolenic Acid - adverse effects</topic><topic>alpha-Linolenic Acid - blood</topic><topic>Biomarkers, Tumor - blood</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>Docosahexaenoic Acids - administration & dosage</topic><topic>Docosahexaenoic Acids - adverse effects</topic><topic>Docosahexaenoic Acids - blood</topic><topic>Eicosapentaenoic Acid - administration & dosage</topic><topic>Eicosapentaenoic Acid - adverse effects</topic><topic>Eicosapentaenoic Acid - blood</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Fatty Acids, Omega-3 - adverse effects</topic><topic>Fatty Acids, Omega-3 - blood</topic><topic>Humans</topic><topic>Neoplasms - blood</topic><topic>Neoplasms - etiology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serini, Simona</creatorcontrib><creatorcontrib>Calviello, Gabriella</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Current opinion in clinical nutrition and metabolic care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serini, Simona</au><au>Calviello, Gabriella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-chain omega-3 fatty acids and cancer: any cause for concern?</atitle><jtitle>Current opinion in clinical nutrition and metabolic care</jtitle><addtitle>Curr Opin Clin Nutr Metab Care</addtitle><date>2018-03</date><risdate>2018</risdate><volume>21</volume><issue>2</issue><spage>83</spage><epage>89</epage><pages>83-89</pages><issn>1363-1950</issn><eissn>1473-6519</eissn><abstract>PURPOSE OF REVIEWRecently, concerns have been raised with regard to the recommended doses of marine long-chain omega-3 polyunsaturated fatty acids (LC-omega-3 PUFAs) especially in relation to cancer risk and treatment. There is urgent need to clarify this point. This review considers the most recent evidence related to the potential risk of developing cancer with high LC-omega-3 PUFA intakes, and possible research strategies to better elucidate this matter.
RECENT FINDINGSThe latest published recommendations have still highlighted the usefulness of an increased dietary intake of LC-omega-3 PUFAs for the prevention of some cardiovascular diseases. However, LC-omega-3 PUFAs have been related to the potential development and progression of cancer, and considerable debate exists on this issue.
SUMMARYThe use of biomarkers reflecting the intake of LC-omega-3 PUFAs as cancer risk markers is discussed, as well as the possibility that the reported beneficial/deleterious effects may be confined to specific subpopulations on the basis of genetic, metabolic, and nutritional characteristics. Recent advances on new strategies for a safer intake of LC-omega-3 PUFAs will be considered, as their dietary sources may be contaminated by toxic/carcinogenic compounds. Potentially future directions in this important research area are also discussed.</abstract><cop>England</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>29232261</pmid><doi>10.1097/MCO.0000000000000439</doi><tpages>7</tpages></addata></record> |
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| ispartof | Current opinion in clinical nutrition and metabolic care, 2018-03, Vol.21 (2), p.83-89 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | alpha-Linolenic Acid - administration & dosage alpha-Linolenic Acid - adverse effects alpha-Linolenic Acid - blood Biomarkers, Tumor - blood Diet Dietary Supplements Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - adverse effects Docosahexaenoic Acids - blood Eicosapentaenoic Acid - administration & dosage Eicosapentaenoic Acid - adverse effects Eicosapentaenoic Acid - blood Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - adverse effects Fatty Acids, Omega-3 - blood Humans Neoplasms - blood Neoplasms - etiology Risk Factors |
| title | Long-chain omega-3 fatty acids and cancer: any cause for concern? |
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