Acute Liver Failure Due to Acetaminophen Poisoning in Patients With Prior Weight Loss Surgery: A Case Series
GOALS:To identify an association between prior weight loss surgery (WLS) and acetaminophen-induced acute liver failure (ALF). BACKGROUND:WLS, which has increased in proportion to the global rise of obesity, alters the absorption and metabolism of many drugs including acetaminophen (APAP) and may pre...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical gastroenterology 2015-10, Vol.49 (9), p.790-793 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 793 |
|---|---|
| container_issue | 9 |
| container_start_page | 790 |
| container_title | Journal of clinical gastroenterology |
| container_volume | 49 |
| creator | Holt, Edward W DeMartini, Sara Davern, Timothy J |
| description | GOALS:To identify an association between prior weight loss surgery (WLS) and acetaminophen-induced acute liver failure (ALF).
BACKGROUND:WLS, which has increased in proportion to the global rise of obesity, alters the absorption and metabolism of many drugs including acetaminophen (APAP) and may predispose to toxicity. No study has identified an association between prior WLS and APAP-ALF.
STUDY:We retrospectively reviewed a cohort of patients who presented to our center with ALF. We identified 101 patients who presented to our center with ALF between January 2009 and December 2011. All patients were prospectively enrolled into a database using consensus criteria. A history of WLS was obtained through a retrospective chart review.
RESULTS:Fifty-four patients (53.5%) had APAP-ALF and 47 (46.5%) had ALF caused by other etiologies. A prior history of WLS was present in 9 of the 54 patients with APAP-ALF versus 0 of the 47 with non-APAP-ALF (P=0.003). Patients with APAP-ALF and prior WLS did not have higher rates of factors commonly associated with APAP overdose, including depression, alcohol abuse, intent to cause self-harm, or use of APAP-narcotic combination drugs.
CONCLUSIONS:A history of WLS may predispose to hepatotoxicity and ALF caused by acetaminophen. |
| doi_str_mv | 10.1097/MCG.0000000000000278 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1097_MCG_0000000000000278</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>25551211</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3058-d622f1d275def36a17f66dd372183ef50a6c0168b6354299f4400df6eaaf1a343</originalsourceid><addsrcrecordid>eNp9kF1LwzAUhoMobk7_gUj-QGc-mrT1blQ3hYqDKbssWXuyRrt2JKlj_97KVMQLz83hwPu8HB6ELikZU5JE14_pbEx-D4viIzSkgicBI5weoyGhCQtIlJABOnPulRAacU5P0YAJISijdIjqSdF5wJl5B4unytSdBXzbAfYtnhTg1cY07baCBs9b49rGNGts-kN5A413eGl8hefWtBYvwawrj7PWObzo7Brs_gZPcKoc4AVYA-4cnWhVO7j42iP0Mr17Tu-D7Gn2kE6yoOBExEEpGdO0ZJEoQXOpaKSlLEseMRpz0IIoWRAq45XkImRJosOQkFJLUEpTxUM-QuGht7D9MxZ0vrVmo-w-pyT_lJf38vK_8nrs6oBtu9UGyh_o21YfiA-BXVt7sO6t7nZg8wpU7av_uz8APX96og</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Acute Liver Failure Due to Acetaminophen Poisoning in Patients With Prior Weight Loss Surgery: A Case Series</title><source>MEDLINE</source><source>Journals@Ovid Ovid Autoload</source><creator>Holt, Edward W ; DeMartini, Sara ; Davern, Timothy J</creator><creatorcontrib>Holt, Edward W ; DeMartini, Sara ; Davern, Timothy J</creatorcontrib><description>GOALS:To identify an association between prior weight loss surgery (WLS) and acetaminophen-induced acute liver failure (ALF).
BACKGROUND:WLS, which has increased in proportion to the global rise of obesity, alters the absorption and metabolism of many drugs including acetaminophen (APAP) and may predispose to toxicity. No study has identified an association between prior WLS and APAP-ALF.
STUDY:We retrospectively reviewed a cohort of patients who presented to our center with ALF. We identified 101 patients who presented to our center with ALF between January 2009 and December 2011. All patients were prospectively enrolled into a database using consensus criteria. A history of WLS was obtained through a retrospective chart review.
RESULTS:Fifty-four patients (53.5%) had APAP-ALF and 47 (46.5%) had ALF caused by other etiologies. A prior history of WLS was present in 9 of the 54 patients with APAP-ALF versus 0 of the 47 with non-APAP-ALF (P=0.003). Patients with APAP-ALF and prior WLS did not have higher rates of factors commonly associated with APAP overdose, including depression, alcohol abuse, intent to cause self-harm, or use of APAP-narcotic combination drugs.
CONCLUSIONS:A history of WLS may predispose to hepatotoxicity and ALF caused by acetaminophen.</description><identifier>ISSN: 0192-0790</identifier><identifier>EISSN: 1539-2031</identifier><identifier>DOI: 10.1097/MCG.0000000000000278</identifier><identifier>PMID: 25551211</identifier><language>eng</language><publisher>United States: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Acetaminophen - administration & dosage ; Acetaminophen - poisoning ; Adult ; Analgesics, Non-Narcotic - administration & dosage ; Analgesics, Non-Narcotic - poisoning ; Bariatric Surgery ; Chemical and Drug Induced Liver Injury - etiology ; Female ; Humans ; Liver Failure, Acute - chemically induced ; Male ; Middle Aged ; Obesity - surgery ; Retrospective Studies ; Risk Factors</subject><ispartof>Journal of clinical gastroenterology, 2015-10, Vol.49 (9), p.790-793</ispartof><rights>Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3058-d622f1d275def36a17f66dd372183ef50a6c0168b6354299f4400df6eaaf1a343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25551211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holt, Edward W</creatorcontrib><creatorcontrib>DeMartini, Sara</creatorcontrib><creatorcontrib>Davern, Timothy J</creatorcontrib><title>Acute Liver Failure Due to Acetaminophen Poisoning in Patients With Prior Weight Loss Surgery: A Case Series</title><title>Journal of clinical gastroenterology</title><addtitle>J Clin Gastroenterol</addtitle><description>GOALS:To identify an association between prior weight loss surgery (WLS) and acetaminophen-induced acute liver failure (ALF).
BACKGROUND:WLS, which has increased in proportion to the global rise of obesity, alters the absorption and metabolism of many drugs including acetaminophen (APAP) and may predispose to toxicity. No study has identified an association between prior WLS and APAP-ALF.
STUDY:We retrospectively reviewed a cohort of patients who presented to our center with ALF. We identified 101 patients who presented to our center with ALF between January 2009 and December 2011. All patients were prospectively enrolled into a database using consensus criteria. A history of WLS was obtained through a retrospective chart review.
RESULTS:Fifty-four patients (53.5%) had APAP-ALF and 47 (46.5%) had ALF caused by other etiologies. A prior history of WLS was present in 9 of the 54 patients with APAP-ALF versus 0 of the 47 with non-APAP-ALF (P=0.003). Patients with APAP-ALF and prior WLS did not have higher rates of factors commonly associated with APAP overdose, including depression, alcohol abuse, intent to cause self-harm, or use of APAP-narcotic combination drugs.
CONCLUSIONS:A history of WLS may predispose to hepatotoxicity and ALF caused by acetaminophen.</description><subject>Acetaminophen - administration & dosage</subject><subject>Acetaminophen - poisoning</subject><subject>Adult</subject><subject>Analgesics, Non-Narcotic - administration & dosage</subject><subject>Analgesics, Non-Narcotic - poisoning</subject><subject>Bariatric Surgery</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Failure, Acute - chemically induced</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - surgery</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>0192-0790</issn><issn>1539-2031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk7_gUj-QGc-mrT1blQ3hYqDKbssWXuyRrt2JKlj_97KVMQLz83hwPu8HB6ELikZU5JE14_pbEx-D4viIzSkgicBI5weoyGhCQtIlJABOnPulRAacU5P0YAJISijdIjqSdF5wJl5B4unytSdBXzbAfYtnhTg1cY07baCBs9b49rGNGts-kN5A413eGl8hefWtBYvwawrj7PWObzo7Brs_gZPcKoc4AVYA-4cnWhVO7j42iP0Mr17Tu-D7Gn2kE6yoOBExEEpGdO0ZJEoQXOpaKSlLEseMRpz0IIoWRAq45XkImRJosOQkFJLUEpTxUM-QuGht7D9MxZ0vrVmo-w-pyT_lJf38vK_8nrs6oBtu9UGyh_o21YfiA-BXVt7sO6t7nZg8wpU7av_uz8APX96og</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Holt, Edward W</creator><creator>DeMartini, Sara</creator><creator>Davern, Timothy J</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201510</creationdate><title>Acute Liver Failure Due to Acetaminophen Poisoning in Patients With Prior Weight Loss Surgery: A Case Series</title><author>Holt, Edward W ; DeMartini, Sara ; Davern, Timothy J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3058-d622f1d275def36a17f66dd372183ef50a6c0168b6354299f4400df6eaaf1a343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acetaminophen - administration & dosage</topic><topic>Acetaminophen - poisoning</topic><topic>Adult</topic><topic>Analgesics, Non-Narcotic - administration & dosage</topic><topic>Analgesics, Non-Narcotic - poisoning</topic><topic>Bariatric Surgery</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Failure, Acute - chemically induced</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - surgery</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holt, Edward W</creatorcontrib><creatorcontrib>DeMartini, Sara</creatorcontrib><creatorcontrib>Davern, Timothy J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of clinical gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holt, Edward W</au><au>DeMartini, Sara</au><au>Davern, Timothy J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute Liver Failure Due to Acetaminophen Poisoning in Patients With Prior Weight Loss Surgery: A Case Series</atitle><jtitle>Journal of clinical gastroenterology</jtitle><addtitle>J Clin Gastroenterol</addtitle><date>2015-10</date><risdate>2015</risdate><volume>49</volume><issue>9</issue><spage>790</spage><epage>793</epage><pages>790-793</pages><issn>0192-0790</issn><eissn>1539-2031</eissn><abstract>GOALS:To identify an association between prior weight loss surgery (WLS) and acetaminophen-induced acute liver failure (ALF).
BACKGROUND:WLS, which has increased in proportion to the global rise of obesity, alters the absorption and metabolism of many drugs including acetaminophen (APAP) and may predispose to toxicity. No study has identified an association between prior WLS and APAP-ALF.
STUDY:We retrospectively reviewed a cohort of patients who presented to our center with ALF. We identified 101 patients who presented to our center with ALF between January 2009 and December 2011. All patients were prospectively enrolled into a database using consensus criteria. A history of WLS was obtained through a retrospective chart review.
RESULTS:Fifty-four patients (53.5%) had APAP-ALF and 47 (46.5%) had ALF caused by other etiologies. A prior history of WLS was present in 9 of the 54 patients with APAP-ALF versus 0 of the 47 with non-APAP-ALF (P=0.003). Patients with APAP-ALF and prior WLS did not have higher rates of factors commonly associated with APAP overdose, including depression, alcohol abuse, intent to cause self-harm, or use of APAP-narcotic combination drugs.
CONCLUSIONS:A history of WLS may predispose to hepatotoxicity and ALF caused by acetaminophen.</abstract><cop>United States</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>25551211</pmid><doi>10.1097/MCG.0000000000000278</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0192-0790 |
| ispartof | Journal of clinical gastroenterology, 2015-10, Vol.49 (9), p.790-793 |
| issn | 0192-0790 1539-2031 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_MCG_0000000000000278 |
| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Acetaminophen - administration & dosage Acetaminophen - poisoning Adult Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - poisoning Bariatric Surgery Chemical and Drug Induced Liver Injury - etiology Female Humans Liver Failure, Acute - chemically induced Male Middle Aged Obesity - surgery Retrospective Studies Risk Factors |
| title | Acute Liver Failure Due to Acetaminophen Poisoning in Patients With Prior Weight Loss Surgery: A Case Series |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T11%3A10%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acute%20Liver%20Failure%20Due%20to%20Acetaminophen%20Poisoning%20in%20Patients%20With%20Prior%20Weight%20Loss%20Surgery:%20A%20Case%20Series&rft.jtitle=Journal%20of%20clinical%20gastroenterology&rft.au=Holt,%20Edward%20W&rft.date=2015-10&rft.volume=49&rft.issue=9&rft.spage=790&rft.epage=793&rft.pages=790-793&rft.issn=0192-0790&rft.eissn=1539-2031&rft_id=info:doi/10.1097/MCG.0000000000000278&rft_dat=%3Cpubmed_cross%3E25551211%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/25551211&rfr_iscdi=true |