Visual scoring of coronary artery calcification in lung cancer screening computed tomography: association with all-cause and cardiovascular mortality risk
OBJECTIVECurrent and former smokers are at an increased risk for lung cancer and cardiovascular disease (CVD). We investigated two methods of visual scoring of coronary artery calcium on lung cancer screening computed tomography (CT) to predict cardiovascular and all-cause mortality. PARTICIPANTS AN...
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| Veröffentlicht in: | Coronary artery disease 2015-03, Vol.26 (2), p.157-162 |
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| creator | Watts, Jubal R Sonavane, Sushilkumar K Snell-Bergeon, Janet Nath, Hrudaya |
| description | OBJECTIVECurrent and former smokers are at an increased risk for lung cancer and cardiovascular disease (CVD). We investigated two methods of visual scoring of coronary artery calcium on lung cancer screening computed tomography (CT) to predict cardiovascular and all-cause mortality.
PARTICIPANTS AND METHODSCases were 1000 participants, age 55–74 years, enrolled in the National Lung Screening Trial CT arm who died during the study. An equal number of participants alive at the end of the study (controls) were matched in terms of sex, CT scanner vendor, and model, and 5-year age and smoking pack-years group. Coronary calcium was measured visually by three readers using two semiquantitative scoring schemes. Conditional logistic regression was used to analyze the association between the presence and the extent of coronary calcium and all-cause and cardiovascular mortality, stratified on matching criteria.
RESULTSCases and controls were well matched for age (64±6 vs. 64±5, P=0.95) and mean pack-years smoking (61±24 vs. 62±24, P=1.0). Cases were significantly more likely to have coronary calcium than controls (85 vs. 77%, P |
| doi_str_mv | 10.1097/MCA.0000000000000189 |
| format | Article |
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PARTICIPANTS AND METHODSCases were 1000 participants, age 55–74 years, enrolled in the National Lung Screening Trial CT arm who died during the study. An equal number of participants alive at the end of the study (controls) were matched in terms of sex, CT scanner vendor, and model, and 5-year age and smoking pack-years group. Coronary calcium was measured visually by three readers using two semiquantitative scoring schemes. Conditional logistic regression was used to analyze the association between the presence and the extent of coronary calcium and all-cause and cardiovascular mortality, stratified on matching criteria.
RESULTSCases and controls were well matched for age (64±6 vs. 64±5, P=0.95) and mean pack-years smoking (61±24 vs. 62±24, P=1.0). Cases were significantly more likely to have coronary calcium than controls (85 vs. 77%, P<0.001). Having any calcium was associated with an increased risk for CVD mortality using either visual scoring method (odds ratio 3.4, 95% confidence interval 2.0–5.6, P<0.001, and odds ratio 3.3, 95% confidence interval 2.0–5.6, P<0.001).
CONCLUSIONVisual scoring of coronary calcium predicts all-cause and CVD mortality in National Lung Screening Trial participants, independent of current versus former smoking status. Visual coronary calcium scoring in low-dose CT scans helps identify individuals at high risk for mortality who may benefit from further CVD prevention.</description><identifier>ISSN: 0954-6928</identifier><identifier>EISSN: 1473-5830</identifier><identifier>DOI: 10.1097/MCA.0000000000000189</identifier><identifier>PMID: 25370000</identifier><language>eng</language><publisher>England: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Aged ; Calcium - metabolism ; Cause of Death ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - mortality ; Coronary Vessels - metabolism ; Female ; Humans ; Lung Neoplasms - diagnostic imaging ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Tomography, X-Ray Computed ; Vascular Calcification - diagnostic imaging ; Vascular Calcification - mortality</subject><ispartof>Coronary artery disease, 2015-03, Vol.26 (2), p.157-162</ispartof><rights>Copyright © Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3429-4d35d6adecf364a761d0cc428a18b5b43b55d1aa457810466cceac518533b85b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25370000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watts, Jubal R</creatorcontrib><creatorcontrib>Sonavane, Sushilkumar K</creatorcontrib><creatorcontrib>Snell-Bergeon, Janet</creatorcontrib><creatorcontrib>Nath, Hrudaya</creatorcontrib><title>Visual scoring of coronary artery calcification in lung cancer screening computed tomography: association with all-cause and cardiovascular mortality risk</title><title>Coronary artery disease</title><addtitle>Coron Artery Dis</addtitle><description>OBJECTIVECurrent and former smokers are at an increased risk for lung cancer and cardiovascular disease (CVD). We investigated two methods of visual scoring of coronary artery calcium on lung cancer screening computed tomography (CT) to predict cardiovascular and all-cause mortality.
PARTICIPANTS AND METHODSCases were 1000 participants, age 55–74 years, enrolled in the National Lung Screening Trial CT arm who died during the study. An equal number of participants alive at the end of the study (controls) were matched in terms of sex, CT scanner vendor, and model, and 5-year age and smoking pack-years group. Coronary calcium was measured visually by three readers using two semiquantitative scoring schemes. Conditional logistic regression was used to analyze the association between the presence and the extent of coronary calcium and all-cause and cardiovascular mortality, stratified on matching criteria.
RESULTSCases and controls were well matched for age (64±6 vs. 64±5, P=0.95) and mean pack-years smoking (61±24 vs. 62±24, P=1.0). Cases were significantly more likely to have coronary calcium than controls (85 vs. 77%, P<0.001). Having any calcium was associated with an increased risk for CVD mortality using either visual scoring method (odds ratio 3.4, 95% confidence interval 2.0–5.6, P<0.001, and odds ratio 3.3, 95% confidence interval 2.0–5.6, P<0.001).
CONCLUSIONVisual scoring of coronary calcium predicts all-cause and CVD mortality in National Lung Screening Trial participants, independent of current versus former smoking status. Visual coronary calcium scoring in low-dose CT scans helps identify individuals at high risk for mortality who may benefit from further CVD prevention.</description><subject>Aged</subject><subject>Calcium - metabolism</subject><subject>Cause of Death</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - mortality</subject><subject>Coronary Vessels - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Vascular Calcification - diagnostic imaging</subject><subject>Vascular Calcification - mortality</subject><issn>0954-6928</issn><issn>1473-5830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EgvL4A4T8A4G4thOHHap4SSA2wDaajB1qcOLKTqj6K3wtrgoIsWA2M4t7rjSHkGOWn7K8Ks_uZxen-e9hqtoiEyZKnknF820yySspsqKaqj2yH-NrighZyl2yN5W8XCMT8vFs4wiORvTB9i_UtzRdvoewohAGkxaCQ9tahMH6ntqeujEFEXo0IXHBmH5Nou8W42A0HXznXwIs5qtzCjF6tBtyaYc5BecyhDEaCr1OJUFb_w4RRweBdj4M4OywosHGt0Oy04KL5uhrH5Cnq8vH2U1293B9O7u4y5CLaZUJzaUuQBtseSGgLJjOEcVUAVONbARvpNQMIL2uWC6KAtEASqYk542SDT8gYtOLwccYTFsvgu2SgJrl9Vp1nVTXf1Un7GSDLcamM_oH-nabAmoTWHqXRMY3Ny5NqOcG3DD_v_sTjR6PMA</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Watts, Jubal R</creator><creator>Sonavane, Sushilkumar K</creator><creator>Snell-Bergeon, Janet</creator><creator>Nath, Hrudaya</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201503</creationdate><title>Visual scoring of coronary artery calcification in lung cancer screening computed tomography: association with all-cause and cardiovascular mortality risk</title><author>Watts, Jubal R ; Sonavane, Sushilkumar K ; Snell-Bergeon, Janet ; Nath, Hrudaya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3429-4d35d6adecf364a761d0cc428a18b5b43b55d1aa457810466cceac518533b85b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Calcium - metabolism</topic><topic>Cause of Death</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - mortality</topic><topic>Coronary Vessels - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Vascular Calcification - diagnostic imaging</topic><topic>Vascular Calcification - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watts, Jubal R</creatorcontrib><creatorcontrib>Sonavane, Sushilkumar K</creatorcontrib><creatorcontrib>Snell-Bergeon, Janet</creatorcontrib><creatorcontrib>Nath, Hrudaya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Coronary artery disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watts, Jubal R</au><au>Sonavane, Sushilkumar K</au><au>Snell-Bergeon, Janet</au><au>Nath, Hrudaya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visual scoring of coronary artery calcification in lung cancer screening computed tomography: association with all-cause and cardiovascular mortality risk</atitle><jtitle>Coronary artery disease</jtitle><addtitle>Coron Artery Dis</addtitle><date>2015-03</date><risdate>2015</risdate><volume>26</volume><issue>2</issue><spage>157</spage><epage>162</epage><pages>157-162</pages><issn>0954-6928</issn><eissn>1473-5830</eissn><abstract>OBJECTIVECurrent and former smokers are at an increased risk for lung cancer and cardiovascular disease (CVD). We investigated two methods of visual scoring of coronary artery calcium on lung cancer screening computed tomography (CT) to predict cardiovascular and all-cause mortality.
PARTICIPANTS AND METHODSCases were 1000 participants, age 55–74 years, enrolled in the National Lung Screening Trial CT arm who died during the study. An equal number of participants alive at the end of the study (controls) were matched in terms of sex, CT scanner vendor, and model, and 5-year age and smoking pack-years group. Coronary calcium was measured visually by three readers using two semiquantitative scoring schemes. Conditional logistic regression was used to analyze the association between the presence and the extent of coronary calcium and all-cause and cardiovascular mortality, stratified on matching criteria.
RESULTSCases and controls were well matched for age (64±6 vs. 64±5, P=0.95) and mean pack-years smoking (61±24 vs. 62±24, P=1.0). Cases were significantly more likely to have coronary calcium than controls (85 vs. 77%, P<0.001). Having any calcium was associated with an increased risk for CVD mortality using either visual scoring method (odds ratio 3.4, 95% confidence interval 2.0–5.6, P<0.001, and odds ratio 3.3, 95% confidence interval 2.0–5.6, P<0.001).
CONCLUSIONVisual scoring of coronary calcium predicts all-cause and CVD mortality in National Lung Screening Trial participants, independent of current versus former smoking status. Visual coronary calcium scoring in low-dose CT scans helps identify individuals at high risk for mortality who may benefit from further CVD prevention.</abstract><cop>England</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>25370000</pmid><doi>10.1097/MCA.0000000000000189</doi><tpages>6</tpages></addata></record> |
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| ispartof | Coronary artery disease, 2015-03, Vol.26 (2), p.157-162 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Calcium - metabolism Cause of Death Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - mortality Coronary Vessels - metabolism Female Humans Lung Neoplasms - diagnostic imaging Male Middle Aged Retrospective Studies Risk Factors Tomography, X-Ray Computed Vascular Calcification - diagnostic imaging Vascular Calcification - mortality |
| title | Visual scoring of coronary artery calcification in lung cancer screening computed tomography: association with all-cause and cardiovascular mortality risk |
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