The role of 20-hydroxyeicosatetraenoic acid in adrenocorticotrophic hormone and dexamethasone-induced hypertension

20-hydroxyeicosatetraenoic acid (20-HETE) is a potent constrictor in small arteries and also has natriuretic properties. Urinary 20-HETE excretion is increased in adrenocorticotrophic hormone (ACTH)-induced hypertensive rats. In the present study, we investigated the effect of a specific enzyme inhi...

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Veröffentlicht in:	Journal of hypertension 2009-08, Vol.27 (8), p.1609-1616
Hauptverfasser:	YI ZHANG, WU, Jason H. Y, VICKERS, Janine J, ONG, Sharon L. H, TEMPLE, Suzanna E. L, MORI, Trevor A, CROFT, Kevin D, WHITWORTH, Judith A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - pharmacology Amidines - pharmacology Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Body Weight - drug effects Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Dexamethasone - pharmacology F2-Isoprostanes - blood Hydroxyeicosatetraenoic Acids - physiology Hypertension - chemically induced Kidney - drug effects Kidney - metabolism Male Medical sciences Organ Size - drug effects Rats Rats, Sprague-Dawley Reactive Nitrogen Species - blood Systole - drug effects
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