Enhancement of receptor-operated cation current and TRPC6 expression in arterial smooth muscle cells of deoxycorticosterone acetate-salt hypertensive rats

In deoxycorticosterone acetate (DOCA)-salt hypertensive rats, altered reactivity of blood vessels to vasoactive agonists is frequently associated with an elevation in blood pressure. Canonical transient receptor potential (TRPC) channels are believed to encode receptor-operated cation channels (ROC)...

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Veröffentlicht in:	Journal of hypertension 2007-04, Vol.25 (4), p.809-817
Hauptverfasser:	YOUNG MIN BAE, KIM, Aeran, SUNG IL CHO, KIM, Duk-Kyung, HO, Won-Kyung, YOUNG JOO LEE, LIM, Wonchung, NOH, Yun-Hee, KIM, Eun-Ju, KIM, Junghwan, KIM, Tae-Kyung, SANG WOONG PARK, KIM, Bokyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone - pharmacology Animals Aorta - cytology Arterial hypertension. Arterial hypotension Arteries - cytology Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood vessels and receptors Blotting, Western Calcium Channels - biosynthesis Calcium Channels - drug effects Cardiology. Vascular system Desoxycorticosterone Disease Models, Animal Experimental diseases Fundamental and applied biological sciences. Psychology Hypertension - chemically induced Hypertension - metabolism Hypertension - physiopathology Medical sciences Mesenteric Artery, Superior - cytology Muscle, Smooth, Vascular - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Norepinephrine - pharmacology Potassium Channels, Calcium-Activated - drug effects Potassium Channels, Calcium-Activated - metabolism Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - drug effects RNA, Messenger - metabolism Serotonin - pharmacology Serotonin Agents - pharmacology TRPC Cation Channels - biosynthesis TRPC Cation Channels - drug effects Up-Regulation - drug effects Vasoconstrictor Agents - pharmacology Vertebrates: cardiovascular system
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