Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals

OBJECTIVESEtravirine (ETV) is metabolized by cytochrome P450 (CYP) 3A, 2C9, and 2C19. Metabolites are glucuronidated by uridine diphosphate glucuronosyltransferases (UGT). To identify the potential impact of genetic and non-genetic factors involved in ETV metabolism, we carried out a two-step pharma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmacogenetics and genomics 2013-01, Vol.23 (1), p.9-18
Hauptverfasser:	Lubomirov, Rubin, Arab-Alameddine, Mona, Rotger, Margalida, Fayet-Mello, Aurélie, Martinez, Raquel, Guidi, Monia, di Iulio, Julia, Cavassini, Matthias, Günthard, Huldrych F, Furrer, Hansjakob, Marzolini, Catia, Bernasconi, Enos, Calmy, Alexandra, Buclin, Thierry, Decosterd, Laurent A, Csajka, Chantal, Telenti, Amalio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aryl Hydrocarbon Hydroxylases - genetics Cytochrome P-450 CYP2C19 Cytochrome P-450 CYP3A - genetics Female HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - genetics HIV Protease Inhibitors - pharmacokinetics HIV Protease Inhibitors - pharmacology HIV-1 - drug effects HIV-1 - genetics Humans Male Middle Aged Models, Statistical Pharmacogenetics Polymorphism, Single Nucleotide - genetics Prognosis Prospective Studies Pyridazines - pharmacokinetics Pyridazines - pharmacology Switzerland - epidemiology Tissue Distribution Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!