Genetic risk factors for type 2 diabetes mellitus and response to sulfonylurea treatment

OBJECTIVEAfter the identification of type 2 diabetes mellitus (T2DM) risk alleles from genome-wide association studies, models have been developed to identify subjects at high risk to develop T2DM. We hypothesize that a panel of 20 repeatedly associated T2DM risk alleles influences response to sulfo...

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Veröffentlicht in:	Pharmacogenetics and genomics 2011-08, Vol.21 (8), p.461-468
Hauptverfasser:	Swen, Jesse J, Guchelaar, Henk-Jan, Baak-Pablo, Renée F, Assendelft, Willem J.J, Wessels, Judith A.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Biomarkers, Pharmacological Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance European Continental Ancestry Group Female General pharmacology Genetic Association Studies Genetic Variation Humans Male Medical sciences Middle Aged Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Polymorphism, Single Nucleotide Risk Factors Sulfonylurea Compounds - therapeutic use
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