A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate

Atopy is a well-defined immune phenotype that is reported to be a risk factor for asthma. Among the many loci that contribute to a genetic predisposition to asthma, the cysteinyl leukotriene receptor genes and their variants have been important subjects of study because they are functionally and pha...

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Veröffentlicht in:	Pharmacogenetics and genomics 2007-07, Vol.17 (7), p.539-549
Hauptverfasser:	Thompson, Miles D, Capra, Valérie, Takasaki, Jun, Maresca, Giovanna, Rovati, G Enrico, Slutsky, Aurther S, Lilly, Craig, Zamel, Noe, McIntyre Burnham, W, Cole, David E, Siminovitch, Katherine A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Animals Asthma - genetics Asthma - immunology Asthma - metabolism Atlantic Islands Base Sequence Biological and medical sciences Calcium Signaling Cell receptors Cell structures and functions Cercopithecus aethiops Chronic obstructive pulmonary disease, asthma COS Cells DNA Primers - genetics Female Fundamental and applied biological sciences. Psychology Gene Frequency General pharmacology Genetic Variation Humans Hypersensitivity, Immediate - genetics Hypersensitivity, Immediate - immunology Hypersensitivity, Immediate - metabolism Inositol Phosphates - metabolism Male Medical sciences Membrane Proteins - genetics Membrane Proteins - immunology Membrane Proteins - metabolism Miscellaneous Molecular and cellular biology Molecular Sequence Data Mutagenesis, Site-Directed Pharmacogenetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Phenotype Pneumology Polymorphism, Single Nucleotide Receptors, Leukotriene - genetics Receptors, Leukotriene - immunology Receptors, Leukotriene - metabolism Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - metabolism Sequence Homology, Amino Acid Transfection
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